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Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
·sciencedirect.com·
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Colin Furness MISt PhD MPH on Twitter
Colin Furness MISt PhD MPH on Twitter

Detailed analysis thread on Twitter: What do we have today? A ton of unexplained child illness in the first cold/flu season since we let COVID rip. Hmm.

We have known since 2020 that COVID harms interferon production, a protein that your cells release to call the immune system for help when they are attacked.

·twitter.com·
Colin Furness MISt PhD MPH on Twitter
Dr. Lisa Iannattone on Twitter
Dr. Lisa Iannattone on Twitter
So it occurred to me that parents should know the warning signs of immunodeficiency in children so that you’ll know when it’s time to ask that your child’s immune system be formally evaluated. These 10 features are all warning signs 🚩 that may warrant further evaluation.
·twitter.com·
Dr. Lisa Iannattone on Twitter
Viral infections like RSV, the flu, and COVID have one Southern California county declaring a pediatric health emergency. It’s far from alone
Viral infections like RSV, the flu, and COVID have one Southern California county declaring a pediatric health emergency. It’s far from alone
“Most kids have had COVID, and there could really be something about COVID affecting children’s immune systems that we haven’t been able to fully understand at this time,” she said.
·fortune.com·
Viral infections like RSV, the flu, and COVID have one Southern California county declaring a pediatric health emergency. It’s far from alone
Pnas
Pnas
A hyperinflammatory syndrome reminiscent of toxic shock syndrome (TSS) is observed in severe COVID-19 patients, including children with Multisystem Inflammatory Syndrome in Children (MIS-C). TSS is typically caused by pathogenic superantigens stimulating excessive activation of the adaptive immune system.
·pnas.org·
Pnas