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John Hess MD on Twitter
John Hess MD on Twitter

Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.

#Immune system#T-cells
·twitter.com·
John Hess MD on Twitter
COVID-19: Study Suggests Long-term Damage to Immune System
COVID-19: Study Suggests Long-term Damage to Immune System
"findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
#Immune system#T-cells
·infectioncontroltoday.com·
COVID-19: Study Suggests Long-term Damage to Immune System
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe

#Immune system#opportunistic infections#T-cells
·twitter.com·
John Hess MD on Twitter
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
#T-cells#opportunistic infections#Immune system
·academic.oup.com·
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Pnas
Pnas

Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?

  • Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
#Immune system#T-cells
·pnas.org·
Pnas
laurie allee on Twitter
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
#Immune system#T-cells#reinfection
·twitter.com·
laurie allee on Twitter
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
#Kids#Immune system#T-cells
·sciencedirect.com·
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Anthony J Leonardi, MBBS, PhD on Twitter
Anthony J Leonardi, MBBS, PhD on Twitter

Detailed analysis on Twitter: "As of now, people choose whether or not they have Long Covid based upon their symptoms

However, if most people, after mild infection have changes to their immune systems like reductions in plasmacytoid dendritic cells, without reporting symptoms, what should this be called?"

#T-cells#Immune system#Long Covid
·twitter.com·
Anthony J Leonardi, MBBS, PhD on Twitter
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
According to a new study, a subset of the naive T-cells from healthy individuals were absent from the recovered individuals. Both COVID19 positive patients & the recovered individuals exhibited a CD40-CD40LG-mediated inflammatory response in the monocytes and T-cell subsets
#T-cells#Immune system
·frontiersin.org·
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
All
All
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19
#T-cells#Immune system
·onlinelibrary.wiley.com·
All
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
#T-cells#Immune system
·frontiersin.org·
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
"Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response."
#T-cells#Immune system#lymphopenia
·ncbi.nlm.nih.gov·
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19