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I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.

Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.

“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”

#AIDS#lymphopenia#T-cells#Immune system
·x.com·
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
"Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response."
#T-cells#Immune system#lymphopenia
·ncbi.nlm.nih.gov·
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
LongCovidPharmD on Twitter
LongCovidPharmD on Twitter

Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.

#lymphopenia#T-cells#Immune system#Long Covid
·twitter.com·
LongCovidPharmD on Twitter