T cell exhaustion in #MECFS & #LongCovid from predominant sympathetic state & the T cells engage the sympathetic fibers & adrenergic signaling decreases their effector function. Sympathetic nerves suppress T-cell responses in infection and in cancer
Sympathetic nerves suppress T-cell responses in infection and in cancer
NIH study identifies features of Long COVID neurological symptoms
"people with Long COVID had lower levels of CD4+ and CD8+ T cells—immune cells involved in coordinating the immune system’s response to viruses—compared to healthy controls."
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2
Anthony J Leonardi, MBBS, PhD on Twitter
Detailed analysis on Twitter: "As of now, people choose whether or not they have Long Covid based upon their symptoms
However, if most people, after mild infection have changes to their immune systems like reductions in plasmacytoid dendritic cells, without reporting symptoms, what should this be called?"
LongCovidPharmD on Twitter
Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.