Detailed analysis of study on Twitter: This is huge. ➡️ 8 months to rebuild T-cell & B-cell count after mild to moderate COVID, which leaves people open to other infections!
It's no wonder many kids are having more severe symptoms.
These viruses are spreading at an exponential rate with unmitigated schools.
Detailed thread on Twitter: "We observe a comparable reduction in B cells in both diseases and a more severe reduction in the total amount of T cells in COVID-19 as compared to AIDS patients."
Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.
Papers that show continuing dysfunction in T-cells: In Long Covid patients: https://nature.com/articles/s41590-021-01113-x In severe Covid-19 disease: https://nature.com/articles/s41418-022-00936-x Precipitates EBV reactivation: https://doi.org/10.1016/j.cell.2022.01.014 Seen in lung damage on autopsy studies:
Expert anecdote: This doctor’s T-cells are way below normal on 5 different T-cell parameters after being #COVID19 infected 5 times! Several studies have found T cell suppression/damage after COVID.
T cell counts of AIDS and COVID19 patients.
"The total absolute numbers of T cells and, in particular of the CD8+ subpopulation, are LOWER in COVID-19 patients compared to AIDS ones, while the CD4+ are reduced in both at similar levels"
Detailed analysis thread on Twitter: People keep asking me if sars cov 2 could alter T cell function to other pathogens and tagging me
Absolutely
And we need to look at T cell "exhaustion" 1/6
A timely and comprehensive review on the unclear contribution of T cells in protecting against SARS-COV-2 disease
The abstract reflects my impressions well. Despite efforts there's poor evidence T cell responses do more than mop up.
SARS Cov 2 has many redundant ways of hiding from cd8 T cells
Did not expect so many!
So the T cells are at a disadvantage
Excellent, detailed analysis by Dr. Akiko Iwasaki on Twitter: In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵
Detailed thread on Twitter: Impressive new study finds Sars Cov 2 has immune suppressive abilities comparable to HIV and that variants increase virus abilities to stop vital anti-viral mechanism in the immune system
Detailed discussion on Twitter: I've gone over in detail with an immunologist just some of the immune system/T-cell problems SARS2 creates, which cause severe disease and possibly Long Covid. Vaccines surely help reduce this, perhaps by half, but do not eliminate the risk completely:
"This is the first report of COVID-19 in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier. HTLV-1 infection can cause immune dysfunction even in asymptomatic carriers."
COVID‐19 in a human T‐cell lymphotropic virus type‐1 carrier
Detailed thread on Twitter: T CELL APOPTOSIS VIA COVID-19: Bombshell new study, done by an elite group of doctors such as @fitterhappierAJ , has found that severity of the disease is correlated to T-cell apoptosis, essentially, your T-cells are contributing to your demise. Very detailed stuff here.
Comprehensive thread on Twitter: Listen up—Top 🇬🇧 scientists warns that “In the last week—there’s now evidence that T-cells…get damaged the same way that HIV and other RNA-virus damage T-cell immunity”. ➡️Prof Costello ( @globalhlthtwit ) raises serious concerns on #COVID19 & the 🧠—a🧵:
Interesting. Uchicago finds in a preprint a strong signature of T cell apoptosis in Covid- more than HIV, and a loss of naive T cells
I wrote about t cell apoptosis and a loss of naive T cells in frontiers in 2020 as being problematic
