T cell apoptosis characterizes severe Covid-19 disease
"Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis."
Dr Satoshi Akima FRACP 『秋間聰』 on Twitter
Lymphocyte exhaustion may persist after recovery from COVID, especially depletion of naive T-cells that are protective of overexuberant cytotoxic T-cell driven responses. This may set up the stage for even more overexuberant T-cell response in future reinfections
Ccr3
"This is the first report of COVID-19 in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier. HTLV-1 infection can cause immune dysfunction even in asymptomatic carriers."
COVID‐19 in a human T‐cell lymphotropic virus type‐1 carrier
SARS News Network (SNN) 🦠 😷 on Twitter
Detailed thread on Twitter: T CELL APOPTOSIS VIA COVID-19: Bombshell new study, done by an elite group of doctors such as @fitterhappierAJ , has found that severity of the disease is correlated to T-cell apoptosis, essentially, your T-cells are contributing to your demise. Very detailed stuff here.
COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: A case report
“This case appears to confirm the concerns that the CD4+ T-cell depletion associated with COVID-19 may promote the development of active tuberculosis from latent infection much like HIV does.”
Eric Feigl-Ding on Twitter
Comprehensive thread on Twitter: Listen up—Top 🇬🇧 scientists warns that “In the last week—there’s now evidence that T-cells…get damaged the same way that HIV and other RNA-virus damage T-cell immunity”. ➡️Prof Costello ( @globalhlthtwit ) raises serious concerns on #COVID19 & the 🧠—a🧵:
Anthony J Leonardi, MBBS, PhD on Twitter
Interesting. Uchicago finds in a preprint a strong signature of T cell apoptosis in Covid- more than HIV, and a loss of naive T cells
I wrote about t cell apoptosis and a loss of naive T cells in frontiers in 2020 as being problematic