Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.
This Science paper buries herd immunity.
Omicron is not a “natural booster”. It actually REDUCED immunity in past-infected triple-vaccinated people.
"Acquired Protein S deficiency commonly occurs in COVID-19, with variable contribution to thromboembolic occurrence... Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis. Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis."
Detailed analysis on Twitter: I have repeatedly said that a chronic SARS-Cov-2 infection is deserving of the same treatment protocol as that of a chronic HIV infection. Hopefully, this thread will finally result in that happening. While looking for Bugs Bunny in a damn rabbit hole, people are suffering.
Blood abnormalities found in people with Long Covid
Study implicates lack of key hormone, damage to immune cells, and reawakened viruses.
Papers that show continuing dysfunction in T-cells: In Long Covid patients: https://nature.com/articles/s41590-021-01113-x In severe Covid-19 disease: https://nature.com/articles/s41418-022-00936-x Precipitates EBV reactivation: https://doi.org/10.1016/j.cell.2022.01.014 Seen in lung damage on autopsy studies:
Expert anecdote: This doctor’s T-cells are way below normal on 5 different T-cell parameters after being #COVID19 infected 5 times! Several studies have found T cell suppression/damage after COVID.
T cell counts of AIDS and COVID19 patients.
"The total absolute numbers of T cells and, in particular of the CD8+ subpopulation, are LOWER in COVID-19 patients compared to AIDS ones, while the CD4+ are reduced in both at similar levels"
Detailed analysis thread on Twitter: People keep asking me if sars cov 2 could alter T cell function to other pathogens and tagging me
Absolutely
And we need to look at T cell "exhaustion" 1/6
A timely and comprehensive review on the unclear contribution of T cells in protecting against SARS-COV-2 disease
The abstract reflects my impressions well. Despite efforts there's poor evidence T cell responses do more than mop up.
SARS Cov 2 has many redundant ways of hiding from cd8 T cells
Did not expect so many!
So the T cells are at a disadvantage
Excellent, detailed analysis by Dr. Akiko Iwasaki on Twitter: In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵
Detailed thread on Twitter: Impressive new study finds Sars Cov 2 has immune suppressive abilities comparable to HIV and that variants increase virus abilities to stop vital anti-viral mechanism in the immune system
Detailed discussion on Twitter: I've gone over in detail with an immunologist just some of the immune system/T-cell problems SARS2 creates, which cause severe disease and possibly Long Covid. Vaccines surely help reduce this, perhaps by half, but do not eliminate the risk completely:
