“Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate >>> lowered immune functioning >>> SARS2.
Get it now?”
exactly.
This is the #Leonardi_Effect
This is exactly what @NjbBari3 and I have been saying for 3 years.
A sustained CD 4 count of <500 will get you there. That's data from HIV positive people.
@dbdugger has the receipts. He too has been warning of this inevitably.
This is a direct result of immune suppression due to Covid infection. HIV does the same thing.
“As the Kansas and Missouri medical communities prepare for respiratory illness season, health officials grapple with an early COVID-19 infection spike and higher-than-normal tuberculosis infections in Wyandotte County.”
T cell exhaustion in #MECFS & #LongCovid from predominant sympathetic state & the T cells engage the sympathetic fibers & adrenergic signaling decreases their effector function. Sympathetic nerves suppress T-cell responses in infection and in cancer
"Molecular Trickery: How Covid Silently Sabotages the Human Immune System... Researchers have discovered that SARS-CoV-2 manipulates the human immune system by forcing cells to produce non-functional proteins, hindering the body’s antiviral defenses."
Study from California State University analyzed immune responses to 35 viruses using data from 219 datasets.
Findings show SARS-CoV-2 triggers a unique cytokine-chemokine profile, distinct from other viruses.
Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.
“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”
“Conclusion Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era. The immunosuppressive nature of the disease and its treatment modalities may contribute to post COVID-19 TB.”
Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.
Anecdote: "My absolute lymphocytes count is below 1 again. My lymphocytes subsets are as bad or worse as they were in 2020. Numbers had normalized in 2022 with Evusheld. So far as I know, I haven't been reinfected. It's not #HIV, but it's acquired immune deficiency. #LongCOVID #AIDS"
Case Study: I’ve got another, mid 60s. In hospital 3 times for FUO. Finally gets Dx coccidioidomycosis septicemia. COVID in February. Persistent lymphocytopenia since then. CD4/CD8 pending but pretty sure what it’s going to show. Worried how often this is going to happen.
Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe
Discussion related to Covid and Microglia: "Microglia enter the room."
From Sept. 2022: "...what impacts has COVID had on your overall immune system?
It’s early days yet. But growing evidence suggests there are changes to your immune system that may put you at risk of other infectious diseases.
Here’s what we know so far:
Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?
Detailed analysis thread of what we know so far about Covid and the immune system: You'd have to ignore a lot of research to say that SARS-CoV-2 infection has no effect on the immune system. So the scientific debate is about how severe, how often, for how long, how much more likely with repeated infections, and how it would manifest in different people.
