Covid flu rsv viruses
"Covid is making flu and other viruses act in unpredictable ways."
Do you keep getting colds after COVID? Here's what we know about how COVID changes your immune system
"I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?"
Viral infections like RSV, the flu, and COVID have one Southern California county declaring a pediatric health emergency. It’s far from alone
“Most kids have had COVID, and there could really be something about COVID affecting children’s immune systems that we haven’t been able to fully understand at this time,” she said.
More than 12,000 students absent from Edmonton schools due to illness
Slowly but surely, media is beginning to introduce post-Covid immune system impairment to explain the tsunami of sick kids in the West.
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health
Study: “persistent T cell abnormalities in convalescent COVID-19 patients more than three months after initial infection.”
In Cleveland and beyond researchers begin to unravel the mystery of long COVID-19
SarsCov2: “…Eerily similar to HIV. McComsey, who has spent the last two decades studying HIV, said that the data they have found so far paints a picture that is eerily familiar.
‘Now I just look at it, and I’m like gosh, it’s like a déjà vu,’…”
2022
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases ” SARS-CoV-2 antigen persistence in infected tissues serves as a basis for postacute COVID-19.”
All
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19
Science
The immunology and immunopathology of COVID-19
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response
Uncertainty around the Long-Term Implications of COVID-19
Oct 1 2021, Title: Uncertainty around the Long-Term Implications of COVID-19 ”perspective on some long-term risks of mutational escape, viral persistence, reinfection, immune dysregulation and neurological and multi-system complications (Long COVID).”
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children
Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children. This paper discusses superantigens in terms of MIS-C in children.
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
"Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response."
Immune suppression in the early stage of COVID-19 disease
Immune suppression in the early stage of COVID-19 disease
Pnas
A hyperinflammatory syndrome reminiscent of toxic shock syndrome (TSS) is observed in severe COVID-19 patients, including children with Multisystem Inflammatory Syndrome in Children (MIS-C). TSS is typically caused by pathogenic superantigens stimulating excessive activation of the adaptive immune system.
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) - PubMed
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
Andrew Ewing on Twitter
Detailed explainer thread with 25 linked studies on Twitter: Immunity debt vs post covid immune deficiency (PCID). Not an immunology expert, but here are 25 papers/articles that collectively argue for PCID. Immunity debt is a made up term that reflects poor science.
TACT on Twitter
Detailed analysis of study on Twitter: This is huge. ➡️ 8 months to rebuild T-cell & B-cell count after mild to moderate COVID, which leaves people open to other infections!
It's no wonder many kids are having more severe symptoms.
These viruses are spreading at an exponential rate with unmitigated schools.
Antonio Caramia on Twitter
Detailed thread on Twitter: "We observe a comparable reduction in B cells in both diseases and a more severe reduction in the total amount of T cells in COVID-19 as compared to AIDS patients."
Anthony J Leonardi, MBBS, PhD on Twitter
Looks like after SARS cov 2 infection the risk of other viral infection Quadrupled
Lymphocytopenia - Hematology and Oncology - MSD Manual Professional Edition
Merck lists Covid as being a leading cause of Lymphocytopenia along with AIDS. Lymphocytopenia is where the body cannot produce enough white blood cells needed to fight infection, cancers etc:
Severe COVID-19 impairs the immune system for longer than 6 months
study confirming the detrimental long-term effects of the coronavirus on the immunesystem akin to #HIV
Small NIH study reveals how immune response triggered by COVID-19 may
"Scientists found evidence that antibodies--proteins produced by the immune system in response to viruses & other invaders--are involved in an attack on cells lining the brain’s blood vessels..." Cross-referenced in thread on Covid brain damage.
Blood-clotting imbalance persists in Long COVID, research finds
In addition to blood clotting disorders, specific cells of the immune system were at abnormal levels long after Covid infection:
Is COVID prematurely aging our immune systems?
"Research is suggesting that T cells, the cells that help produce antibodies and kill infected cells, are taking a particular hit, and that repeated SARS-CoV-2 infections may be prematurely aging human immune systems."
Chris Turnbull on Twitter
HIV-like mechanism of SarsCov2 Detailed explainer thread on Twitter: 1/ New Research: HIV-like mechanism of immune system destruction found in Sars Cov 2 (Covid 19) infection.
Sars 2 has now been found to infect the immune system directly causing immune system cell death and depletion using a mechanism similar to HIV.
Evidence brief ba4 ba5 risk assessment jul 8
"Evidence shows that SARS-CoV-2 reinfection adds risk of all-cause mortality, hospitalization and adverse health outcomes during acute and post-acute SARS-CoV-2 reinfection, and that the risk and burden may increase in a graded manner according to the number of infections. The evidence that SARS-CoV-2 can cause immune dysregulation is increasing."
Chris Turnbull on Twitter
Detailed analysis on Twitter: Covid, Sars 2: Public Health Canada finally admits and warns about 'immune dysregulation' caused by the virus which could have 'significant impact on the incidence and associated burden of infectious diseases' in latest briefing and that reinfection increases chances of death