Search Covid and the Immune System

Getting COVID-19 Could Weaken Your Immune System

"Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses."

#T-cells #Immune system #reinfection

·time.com·Jun 14, 2023

Getting COVID-19 Could Weaken Your Immune System

COVID left some with damaged immune response, study finds

"You have damage that, even in recovery from the infection, you haven't really recovered your ability to make those CD8+ cells. So something happened in the course of infection to prevent that, to damage your response,"

#Immune system #T-cells

·cbsnews.com·Jun 14, 2023

COVID left some with damaged immune response, study finds

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

"Our data demonstrate that the human thymus is a target of SARS-CoV-2 and thymic function is altered following infection. These findings expand our current knowledge of the effects of SARS-CoV-2 infection on T-cell homeostasis..."

#T-cells #Immune system #thymus

·sciencedirect.com·Jun 14, 2023

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health

#Immune system #T-cells

·frontiersin.org·Jun 14, 2023

Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health

TONSILS ARE MAJOR SITES OF PROLONGED SARS-COV-2 INFECTION IN CHILDREN

#Immune system #Kids #tonsils

·medrxiv.org·Jun 14, 2023

TONSILS ARE MAJOR SITES OF PROLONGED SARS-COV-2 INFECTION IN CHILDREN

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COVID-19’s immuno-pathology and cardiovascular diseases

#vascular #Heart #Immune system

·journals.sagepub.com·Jun 14, 2023

10815589221141841

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.

#Kids #Immune system #T-cells

·sciencedirect.com·Jun 14, 2023

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines

#T-cells #antihistamines #Long Covid #Immune system

·jim.bmj.com·Jun 14, 2023

Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines

Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia

Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection:

#Immune system #lymphocytosis

·mdpi.com·Jun 14, 2023

Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

#Immune system #Long Covid

·nature.com·Jun 14, 2023

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

ARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

#Immune system #thymus

·sciencedirect.com·Jun 14, 2023

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

#Long Covid #Immune system #T-cells

·biorxiv.org·Jun 14, 2023

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis

#oncolytic #Immune system #female #cancer

·sciencedirect.com·Jun 14, 2023

COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis

SARS-CoV-2 as an Oncolytic Virus Following Reactivation of the Immune System: A Review

#Immune system #oncolytic

·mdpi.com·Jun 14, 2023

SARS-CoV-2 as an Oncolytic Virus Following Reactivation of the Immune System: A Review

The T cell immune response against SARS-CoV-2

80% of peripheral T cells die during SARS Cov 2 infection, with proliferation of 20% of the CD8 T cell pool

#T-cells #Immune system

·nature.com·Jun 14, 2023

The T cell immune response against SARS-CoV-2

COVID-19 Impairs Immune Response to Candida albicans

#opportunistic infections #Immune system #reinfection

·frontiersin.org·Jun 14, 2023

COVID-19 Impairs Immune Response to Candida albicans

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

#Immune system

·nature.com·Jun 14, 2023

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

#Immune system

·sciencedirect.com·Jun 14, 2023

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

#Clots #vascular #Immune system

·nature.com·Jun 14, 2023

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

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The bullwhip effect, T-cell telomeres, and SARS-CoV-2

#T-cells #Immune system

·thelancet.com·Jun 14, 2023

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Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC Medicine

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

#Immune system

·bmcmedicine.biomedcentral.com·Jun 14, 2023

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC Medicine

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

#Immune system

·nature.com·Jun 14, 2023

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

“T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted.”

#T-cells #Immune system

·frontiersin.org·Jun 14, 2023

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

SARS-CoV-2 infection weakens immune-cell response to vaccination

"...these findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."

#Immune system #T-cells

·nih.gov·Jun 14, 2023

SARS-CoV-2 infection weakens immune-cell response to vaccination

Daniel Brittain Dugger on Twitter

Detailed Twitter thread: Acquired lymphocytopenia The most common causes include: Protein-energy undernutrition AIDS COVID-19 Certain other viral infections

#lympocytopenia #Immune system

·twitter.com·Jun 14, 2023

Daniel Brittain Dugger on Twitter

SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing

The Sarbecovirus subgenus has special ORF genes that suppress key components of the immune system

#Immune system

·biorxiv.org·Jun 14, 2023

SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing

SARS-CoV-2 Actively Infects And Kills Lymphoid Cells

#lymphopenia #Immune system

·forbes.com·Jun 14, 2023

SARS-CoV-2 Actively Infects And Kills Lymphoid Cells

Immune systems seriously weakened by COVID

"...at least three studies show COVID-19 actually kills off a significant number of the body’s T-cells, so even when a someone recovers from COVID, they are at a heightened risk for other viral, bacterial and fungal infections."

#Immune system #T-cells #reinfection #opportunistic infections

·therecord.com·Jun 14, 2023

Immune systems seriously weakened by COVID

WesElyMD on Twitter

Detailed study analysis and commentary on Twitter: "/🧵 Our cell’s genes are rewired in MILD COVID 🧬

Stunning data in @Nature

White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.

We’re immunocompromised.

Let’s unpack this…"

#Immune system

·twitter.com·Jun 14, 2023

WesElyMD on Twitter

SharonBC,Canada on Twitter

Part 1 of 2 A study which supports the theory of Immune DisRegulation. Dr Zacharey Rubin is a paediatric allergist and immunologist. He is on TikTok as @ rubin_allergy.

#T-cells #Immune system #reinfection #opportunistic infections

·twitter.com·Jun 14, 2023

SharonBC,Canada on Twitter