Detailed analysis on Twitter:
"As of now, people choose whether or not they have Long Covid based upon their symptoms
However, if most people, after mild infection have changes to their immune systems like reductions in plasmacytoid dendritic cells, without reporting symptoms, what should this be called?"
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
According to a new study, a subset of the naive T-cells from healthy individuals were absent from the recovered individuals. Both COVID19 positive patients & the recovered individuals exhibited a CD40-CD40LG-mediated inflammatory response in the monocytes and T-cell subsets
Detailed analysis thread on Twitter:
What do we have today? A ton of unexplained child illness in the first cold/flu season since we let COVID rip. Hmm.
We have known since 2020 that COVID harms interferon production, a protein that your cells release to call the immune system for help when they are attacked.
So it occurred to me that parents should know the warning signs of immunodeficiency in children so that you’ll know when it’s time to ask that your child’s immune system be formally evaluated. These 10 features are all warning signs 🚩 that may warrant further evaluation.
Opinion: Kids are suffering from COVID in ways we never expected
"What we are likely seeing, he says, is “immunity robbery,” where COVID infection stealthily hobbles the immune system, even in those who don’t suffer severe illness, like many children."
Viral infections like RSV, the flu, and COVID have one Southern California county declaring a pediatric health emergency. It’s far from alone
“Most kids have had COVID, and there could really be something about COVID affecting children’s immune systems that we haven’t been able to fully understand at this time,” she said.
In Cleveland and beyond researchers begin to unravel the mystery of long COVID-19
SarsCov2: “…Eerily similar to HIV. McComsey, who has spent the last two decades studying HIV, said that the data they have found so far paints a picture that is eerily familiar.
‘Now I just look at it, and I’m like gosh, it’s like a déjà vu,’…”
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases
” SARS-CoV-2 antigen persistence in infected tissues serves as a basis for postacute COVID-19.”
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation
Uncertainty around the Long-Term Implications of COVID-19
Oct 1 2021, Title: Uncertainty around the Long-Term Implications of COVID-19
”perspective on some long-term risks of mutational escape, viral persistence, reinfection, immune dysregulation and neurological and multi-system complications (Long COVID).”
HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children
Mar 11 2021, Title, HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children.
This paper discusses superantigens in terms of MIS-C in children.
Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19
"Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response."
A hyperinflammatory syndrome reminiscent of toxic shock syndrome (TSS) is observed in severe COVID-19 patients, including children with Multisystem Inflammatory Syndrome in Children (MIS-C). TSS is typically caused by pathogenic superantigens stimulating excessive activation of the adaptive immune system.
Detailed explainer thread with 25 linked studies on Twitter:
Immunity debt vs post covid immune deficiency (PCID).
Not an immunology expert, but here are 25 papers/articles that collectively argue for PCID.
Immunity debt is a made up term that reflects poor science.
Detailed analysis of study on Twitter:
This is huge. ➡️ 8 months to rebuild T-cell & B-cell count after mild to moderate COVID, which leaves people open to other infections!
It's no wonder many kids are having more severe symptoms.
These viruses are spreading at an exponential rate with unmitigated schools.