Antonio Caramia on Twitter
Detailed thread on Twitter: "We observe a comparable reduction in B cells in both diseases and a more severe reduction in the total amount of T cells in COVID-19 as compared to AIDS patients."
Anthony J Leonardi, MBBS, PhD on Twitter
Looks like after SARS cov 2 infection the risk of other viral infection Quadrupled
Lymphocytopenia - Hematology and Oncology - MSD Manual Professional Edition
Merck lists Covid as being a leading cause of Lymphocytopenia along with AIDS. Lymphocytopenia is where the body cannot produce enough white blood cells needed to fight infection, cancers etc:
Severe COVID-19 impairs the immune system for longer than 6 months
study confirming the detrimental long-term effects of the coronavirus on the immunesystem akin to #HIV
Small NIH study reveals how immune response triggered by COVID-19 may
"Scientists found evidence that antibodies--proteins produced by the immune system in response to viruses & other invaders--are involved in an attack on cells lining the brain’s blood vessels..." Cross-referenced in thread on Covid brain damage.
Blood-clotting imbalance persists in Long COVID, research finds
In addition to blood clotting disorders, specific cells of the immune system were at abnormal levels long after Covid infection:
Is COVID prematurely aging our immune systems?
"Research is suggesting that T cells, the cells that help produce antibodies and kill infected cells, are taking a particular hit, and that repeated SARS-CoV-2 infections may be prematurely aging human immune systems."
Chris Turnbull on Twitter
HIV-like mechanism of SarsCov2 Detailed explainer thread on Twitter: 1/ New Research: HIV-like mechanism of immune system destruction found in Sars Cov 2 (Covid 19) infection.
Sars 2 has now been found to infect the immune system directly causing immune system cell death and depletion using a mechanism similar to HIV.
Evidence brief ba4 ba5 risk assessment jul 8
"Evidence shows that SARS-CoV-2 reinfection adds risk of all-cause mortality, hospitalization and adverse health outcomes during acute and post-acute SARS-CoV-2 reinfection, and that the risk and burden may increase in a graded manner according to the number of infections. The evidence that SARS-CoV-2 can cause immune dysregulation is increasing."
Chris Turnbull on Twitter
Detailed analysis on Twitter: Covid, Sars 2: Public Health Canada finally admits and warns about 'immune dysregulation' caused by the virus which could have 'significant impact on the incidence and associated burden of infectious diseases' in latest briefing and that reinfection increases chances of death
Enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants BA.4 and BA.5
BA.5 has improved ability compared to BA.1 to 𝙨𝙪𝙥𝙥𝙧𝙚𝙨𝙨 𝙝𝙤𝙨𝙩 𝙞𝙢𝙢𝙪𝙣𝙚 𝙧𝙚𝙨𝙥𝙤𝙣𝙨𝙚𝙨.
Higher disease severity of BA.5 is 𝙣𝙤𝙩 𝙤𝙣𝙡𝙮 due to immune evasiveness, but also suppression of host immune responses.
charlos on Twitter
Medical anecdote: Hey #LongCovid & #MedTwitter does low CD4 definitely mean immunodeficiency or can there be a number of factors? My results are pretty low (HIV levels), & I know this was just documented in a LC study ~ does this mean we’re experiencing immunodeficiency -or am I missing something?
Kashif Pirzada, MD on Twitter
Medical anecdote: Seeing a lot of lymphopenia (low CD4, CD8 white blood cells) in ER patients these days. Seems to be over represented in those getting admitted to hospital, mostly for reasons unrelated to Covid. Are any clinician colleagues seeing the same?
dr jack lambert on Twitter
I do lymphocyte subsets on all long covid when possible. Many have low cd4 lymphocytes just like hiv.. I have documented reactivation of cmv. Ebv zoster. This is scarily similar to hiv induced immunosuppressive
LongCovidPharmD on Twitter
Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.
People who caught Covid in first wave get ‘no immune boost’ from Omicron
This Science paper buries herd immunity.
Omicron is not a “natural booster”. It actually REDUCED immunity in past-infected triple-vaccinated people.
Beneficial Immune Regulation by Biological Response Modifier Glucans in COVID-19 and Their Envisaged Potentials in the Management of Sepsis
".. COVID-19-induced organ damage and death are due to immunosuppression, especially CD4+ and CD8+ T-cell lymphopenia. This lymphopenia is.. leading to increased secondary infections.. it is clear that COVID-19 closely resembles sepsis.."
laurie allee on Twitter
Starting thread on increased susceptibility to other infections / opportunistic infections / flares of chronic infections after acute SarsCov2. (Adding to thread started below. Some if this is cross-listed in my threads on T-cells and immune system damage.)
Amy Mitchell on Twitter
The Immune Deficiency Foundation explained that all cases of COVID cause some degree of immune suppression. See their explanation to my question in this video.
laurie allee on Twitter
"Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis."
laurie allee on Twitter
Starting thread on lymphopenia after Covid infection. Some of this is cross-referenced in my thread on Covid and T-cells -- which is also serving as a general thread on Covid and lowered immunity.
Study investigates the cause of lymphopenia as seen in COVID-19 patients
Study investigates the cause of lymphopenia as seen in COVID-19 patients
Dysregulation of Protein S in COVID-19
"Acquired Protein S deficiency commonly occurs in COVID-19, with variable contribution to thromboembolic occurrence... Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis. Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis."
2020
The following article, SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes
Daniel Brittain Dugger on Twitter
Detailed analysis on Twitter: I have repeatedly said that a chronic SARS-Cov-2 infection is deserving of the same treatment protocol as that of a chronic HIV infection. Hopefully, this thread will finally result in that happening. While looking for Bugs Bunny in a damn rabbit hole, people are suffering.
Blood abnormalities found in people with Long Covid
Blood abnormalities found in people with Long Covid
Study implicates lack of key hormone, damage to immune cells, and reawakened viruses.
T cell apoptosis characterizes severe Covid-19 disease
"our results are compatible with a model in which T-cell apoptosis accounts for T lymphopenia in individuals with severe COVID-19."
Multiple early factors anticipate post-acute COVID-19 sequelae
Papers that show continuing dysfunction in T-cells: In Long Covid patients: https://nature.com/articles/s41590-021-01113-x In severe Covid-19 disease: https://nature.com/articles/s41418-022-00936-x Precipitates EBV reactivation: https://doi.org/10.1016/j.cell.2022.01.014 Seen in lung damage on autopsy studies:
Dr Kerry Smith on Twitter
Expert anecdote: This doctor’s T-cells are way below normal on 5 different T-cell parameters after being #COVID19 infected 5 times! Several studies have found T cell suppression/damage after COVID.
Antonio Caramia on Twitter
T cell counts of AIDS and COVID19 patients.
"The total absolute numbers of T cells and, in particular of the CD8+ subpopulation, are LOWER in COVID-19 patients compared to AIDS ones, while the CD4+ are reduced in both at similar levels"