Covid and the Immune System

Covid and the Immune System

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Why scientists are rethinking the immune effects of SARS-CoV-2
Why scientists are rethinking the immune effects of SARS-CoV-2

Covid weakens your immune system. You are less likely to fight off pathogens and that is why you are “always sick”. '“There has definitely been a change in the character of the immune response since 2019,” says Tim Henrich, immunologist and senior author of the study. “It’s certainly impacting our immune health, and probably our overall health as well.”'

·bmj.com·
Why scientists are rethinking the immune effects of SARS-CoV-2
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
“We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.”
·flip.it·
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
“In the midst of the global pandemic, a curious phenomenon has emerged: some individuals seem to evade the grips of COVID-19 entirely, even when exposed. This mysterious resilience has sparked a wave of scientific curiosity and investigation. Could it be that some people are naturally immune to COVID-19 and other viruses? As we delve into this intriguing topic, we unravel the complex interplay of genetics, environment, and immune system dynamics that may hold the key to this enigma.”
·flip.it·
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
“In conclusion, our findings demonstrate that immunomodulatory changes in both myeloid and lymphoid cells can persist for up to 17 months following COVID-19, even in individuals who experienced only MILD illness.”m
·onlinelibrary.wiley.com·
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Study analyzed blood from 65 Long COVID patients & found reduced immunoglobulin levels and persistent SARS‑CoV‑2 antigens (spike and nucleocapsid proteins). They used targeted mass spectrometry to measure SARS‑CoV‑2 spike & nucleocapsid proteins in plasma specifically
·sciencedirect.com·
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Study says original COVID-19 vaccination did not stop immune system from fighting variants
Study says original COVID-19 vaccination did not stop immune system from fighting variants
“Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study led by researchers at the University of Arizona Health Sciences and published in Nature Immunology.”
·flip.it·
Study says original COVID-19 vaccination did not stop immune system from fighting variants
Research: COVID Virus Turns Fighters Into Suppressors
Research: COVID Virus Turns Fighters Into Suppressors
New research from Johns Hopkins finds that white blood cells may be altered by SARS2 to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus
·miragenews.com·
Research: COVID Virus Turns Fighters Into Suppressors
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
Here's really strong evidence of immune damage from COVID among bacterial infections with no vaccines. Look at the sharp climbs in all since 2020.
·gov.uk·
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
A study new finds that neutrophils—the most abundant white blood cells in humans—may be altered by SARS-CoV-2 virus to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus.
·science.org·
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS

Diagnostic Criteria for MCAS activated by LongCOVID & Post-Vaccination Syndrome PVS

·researchgate.net·
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology

New study shows that SARS-CoV2 Spike Proteins induces Mast Cell Activation and MCAS

·journals.asm.org·
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
The Proof of Immune Harm Is In The Pudding
The Proof of Immune Harm Is In The Pudding
“Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.”
Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.
·easychair.info·
The Proof of Immune Harm Is In The Pudding
Is COVID quietly sabotaging our immune systems?
Is COVID quietly sabotaging our immune systems?
“Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections”
Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections
·canadianaffairs.news·
Is COVID quietly sabotaging our immune systems?
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study

Covid and the immune system

A large-scale sample of Covid survivors and controls with a negative Covid test, showed Covid survivors were more prone to infections like bacterial infections and herpesviruses reactivation in the 12 month post Covid

·thelancet.com·
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
“a positive test for COVID-19 is associated with increased rates of diagnosis of various non–SARS-CoV-2 infections in the 12 months following an acute SARS-CoV-2 infection, even if the initial infection is mild to moderate.”
·cidrap.umn.edu·
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
Kids keep getting sicker as evidence for COVID immune damage builds
Kids keep getting sicker as evidence for COVID immune damage builds
“Through it all, governments and media grasped for any explanation that did not feature the collapse of public health and introduction of a novel virus that harms immune systems.”
·open.substack.com·
Kids keep getting sicker as evidence for COVID immune damage builds