SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity
ARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity
Covid and the Immune System
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2
COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis
COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis
SARS-CoV-2 as an Oncolytic Virus Following Reactivation of the Immune System: A Review
SARS-CoV-2 as an Oncolytic Virus Following Reactivation of the Immune System: A Review
The T cell immune response against SARS-CoV-2
80% of peripheral T cells die during SARS Cov 2 infection, with proliferation of 20% of the CD8 T cell pool
COVID-19 Impairs Immune Response to Candida albicans
COVID-19 Impairs Immune Response to Candida albicans
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
Fulltext
The bullwhip effect, T-cell telomeres, and SARS-CoV-2
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC Medicine
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
“T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted.”
SARS-CoV-2 infection weakens immune-cell response to vaccination
"...these findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
Daniel Brittain Dugger on Twitter
Detailed Twitter thread: Acquired lymphocytopenia The most common causes include: Protein-energy undernutrition AIDS COVID-19 Certain other viral infections
SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing
The Sarbecovirus subgenus has special ORF genes that suppress key components of the immune system
COVID-19 and Immune Dysregulation, a Summary and Resource - WHN
COVID-19 and Immune Dysregulation, a Summary and Resource:
SARS-CoV-2 Actively Infects And Kills Lymphoid Cells
SARS-CoV-2 Actively Infects And Kills Lymphoid Cells
Immune systems seriously weakened by COVID
"...at least three studies show COVID-19 actually kills off a significant number of the body’s T-cells, so even when a someone recovers from COVID, they are at a heightened risk for other viral, bacterial and fungal infections."
WesElyMD on Twitter
Detailed study analysis and commentary on Twitter: "/🧵 Our cell’s genes are rewired in MILD COVID 🧬
Stunning data in @Nature
White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.
We’re immunocompromised.
Let’s unpack this…"
SharonBC,Canada on Twitter
Part 1 of 2 A study which supports the theory of Immune DisRegulation. Dr Zacharey Rubin is a paediatric allergist and immunologist. He is on TikTok as @ rubin_allergy.
Anthony J Leonardi, MBBS, PhD on Twitter
Detailed analysis on Twitter: "As of now, people choose whether or not they have Long Covid based upon their symptoms
However, if most people, after mild infection have changes to their immune systems like reductions in plasmacytoid dendritic cells, without reporting symptoms, what should this be called?"
Accelerated biological aging in COVID-19 patients
the gravity of reinfecting Covid's immunity damage
Measles immunity amnesia is a one-off thing
Covid reinfects and the harm to the immune system is worse and easier to appreciate
T cells are aged
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
According to a new study, a subset of the naive T-cells from healthy individuals were absent from the recovered individuals. Both COVID19 positive patients & the recovered individuals exhibited a CD40-CD40LG-mediated inflammatory response in the monocytes and T-cell subsets
Had one infection after another this year? There are good reasons why many of us keep getting sick
Australian immunologists discuss the impact of COVID-19 on the immune system, and how this could worsen future risk for other infections.
It has to do with altered function or reprogramming of immune cells, rather than depleted numbers.
Colin Furness MISt PhD MPH on Twitter
Detailed analysis thread on Twitter: What do we have today? A ton of unexplained child illness in the first cold/flu season since we let COVID rip. Hmm.
We have known since 2020 that COVID harms interferon production, a protein that your cells release to call the immune system for help when they are attacked.
‘Immunity debt’: Why experts say this new term promotes COVID-19 ‘misinformation’ - National | Globalnews.ca
So why are so many kids experiencing severe illness from seasonal viruses?
Emerging evidence suggests COVID-19 may be to blame
Dr. Lisa Iannattone on Twitter
So it occurred to me that parents should know the warning signs of immunodeficiency in children so that you’ll know when it’s time to ask that your child’s immune system be formally evaluated. These 10 features are all warning signs 🚩 that may warrant further evaluation.
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Opinion: Kids are suffering from COVID in ways we never expected
"What we are likely seeing, he says, is “immunity robbery,” where COVID infection stealthily hobbles the immune system, even in those who don’t suffer severe illness, like many children."
What If COVID Reinfections Wear Down Our Immunity? | The Tyee
But what if COVID wears down T cells in people who get it, and does so increasingly with each reinfection?