Covid and the Immune System

Covid and the Immune System

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Missing immune cells may explain why COVID-19 vaccine protection quickly wanes
Missing immune cells may explain why COVID-19 vaccine protection quickly wanes

“Neither (MRNA) vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure.

The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs).

All study participants had received between two to five doses of messenger RNA (mRNA) COVID-19 vaccines—which code for SARS-CoV-2’s spike—during the preceding 3 years.

Neither vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure. The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs).
·science.org·
Missing immune cells may explain why COVID-19 vaccine protection quickly wanes
Over but not gone: lingering epigenetic effects of COVID-19
Over but not gone: lingering epigenetic effects of COVID-19

“Long COVID’ affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.”

·sciencedirect.com·
Over but not gone: lingering epigenetic effects of COVID-19
"Long COVID, or post-acute COVID syndrome (PACS), is now estimated to occur in 19% of adults having presented with COVID-19..
"Long COVID, or post-acute COVID syndrome (PACS), is now estimated to occur in 19% of adults having presented with COVID-19..

“Long COVID, or post-acute COVID syndrome (PACS), is now estimated to occur in 19% of adults having presented with COVID-19.. PACS is believed to be caused by immunological changes that persist after acute infection. Furthermore, it is now increasingly recognized that these changes include not only those in the adaptive immune system, such as production of autoantibodies or autoreactive T cells due to molecular mimicry, but also those in the innate immune system.. A new study by Cheong et al. in Cell reveals crucial differences in the transcriptional and epigenetic state of innate immune cells and their progenitors [among PASC patients].. the study team demonstrated that myeloid cells and hematopoietic progenitor cells harbored transcriptional and chromatin accessibility changes that did not return to baseline even 1 year after acute SARS-CoV-2 infection. These data provide powerful evidence that persistent changes (i.e., trained immunity) may underlie PACS..”

·x.com·
"Long COVID, or post-acute COVID syndrome (PACS), is now estimated to occur in 19% of adults having presented with COVID-19..
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵
“SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination”
·x.com·
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵
In a recent interview, Fauci puts the C19 herd immunity fantasy to bed once and for all. No such thing can ever be achieved, due to lack of immune response durability
In a recent interview, Fauci puts the C19 herd immunity fantasy to bed once and for all. No such thing can ever be achieved, due to lack of immune response durability

“In a recent interview, Fauci puts the C19 herd immunity fantasy to bed once and for all. No such thing can ever be achieved, due to lack of immune response durability”

·x.com·
In a recent interview, Fauci puts the C19 herd immunity fantasy to bed once and for all. No such thing can ever be achieved, due to lack of immune response durability
Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies
Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies

This is from 2021. We never heard about it again.

“As part of a new study on hybrid immunity to the virus, the large, multi-institution research team led by The University of Texas at Austin discovered and isolated a broadly neutralizing plasma antibody, called SC27, from a single patient. Using technology developed over several years of research into antibody response, the team led by UT engineers and scientists obtained the exact molecular sequence of the antibody, opening the possibility of manufacturing it on a larger scale for future treatments.”

·news.utexas.edu·
Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies
Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate lowered immune functioning SARS2.
Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate lowered immune functioning SARS2.

“Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate >>> lowered immune functioning >>> SARS2.

Get it now?”

·x.com·
Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate lowered immune functioning SARS2.
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
"We... conclusively demonstrate that SARS-CoV-2 is capable of infecting and replicating within [the heart, lymph nodes, small intestine, adrenal glands] and many other tissues, including brain... as late as 230 days following symptom onset..."
·nature.com·
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
I've been saying this since Mar 2020, when COVID caused lymphocytopenia in the first month of my infection. Once I was finally able to get a lymphocytes subsets panel in Dec 2020, I shared my knowledge but couldn't find an audience who'd listen. No one wanted to believe
I've been saying this since Mar 2020, when COVID caused lymphocytopenia in the first month of my infection. Once I was finally able to get a lymphocytes subsets panel in Dec 2020, I shared my knowledge but couldn't find an audience who'd listen. No one wanted to believe
·x.com·
I've been saying this since Mar 2020, when COVID caused lymphocytopenia in the first month of my infection. Once I was finally able to get a lymphocytes subsets panel in Dec 2020, I shared my knowledge but couldn't find an audience who'd listen. No one wanted to believe
Kansas COVID-19 spike coincides with unexplained tuberculosis infections • Kansas Reflector
Kansas COVID-19 spike coincides with unexplained tuberculosis infections • Kansas Reflector

This is a direct result of immune suppression due to Covid infection. HIV does the same thing.

“As the Kansas and Missouri medical communities prepare for respiratory illness season, health officials grapple with an early COVID-19 infection spike and higher-than-normal tuberculosis infections in Wyandotte County.”

·kansasreflector.com·
Kansas COVID-19 spike coincides with unexplained tuberculosis infections • Kansas Reflector
Molecular Trickery: How COVID-19 Silently Sabotages the Human Immune System
Molecular Trickery: How COVID-19 Silently Sabotages the Human Immune System

"Molecular Trickery: How Covid Silently Sabotages the Human Immune System... Researchers have discovered that SARS-CoV-2 manipulates the human immune system by forcing cells to produce non-functional proteins, hindering the body’s antiviral defenses."

·scitechdaily.com·
Molecular Trickery: How COVID-19 Silently Sabotages the Human Immune System
Immunoprofiles of COVID-19 uniquely differentiated from other viruses: A machine learning investigation of multiplex immunoassay data | PNAS Nexus | Oxford Academic
Immunoprofiles of COVID-19 uniquely differentiated from other viruses: A machine learning investigation of multiplex immunoassay data | PNAS Nexus | Oxford Academic

Study from California State University analyzed immune responses to 35 viruses using data from 219 datasets.

Findings show SARS-CoV-2 triggers a unique cytokine-chemokine profile, distinct from other viruses.

·academic.oup.com·
Immunoprofiles of COVID-19 uniquely differentiated from other viruses: A machine learning investigation of multiplex immunoassay data | PNAS Nexus | Oxford Academic
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.

Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.

“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”

·x.com·
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
“I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency. #AIDS #longCOVID “
·x.com·
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Covid causes long-term reduction of immune system cells." Significantly, researchers found those infected (who had mild symptoms) had similar immune function to the non-infected group 10 weeks post-covid, but much reduced immune function at 10 months
·onlinelibrary.wiley.com·
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19

A grim reality for SARS-CoV-2 survivors

Severe and lasting damage to their immune systems

·onlinelibrary.wiley.com·
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."

‘“Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era.’

In only 3 years we discovered this.

HIV, discovered in 1981? Took until the early 90s.

And yet, the @CDC_TB never tells people to avoid C0Vid.”

·x.com·
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."