Severe COVID-19 can cause persistent alterations in the innate immune system, leading to high levels of inflammation even after recovery.
Changes in gene expression in blood-forming stem cells were found, which were passed down to immune cells.
COVID-19 rapidly increases senescent and exhausted T cells, particularly CD4 and CD8 T cells.
Both mild and severe COVID-19 cases showed increased markers of T-cell exhaustion and senescence with more pronounced changes in severe cases.
“Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
HIV/AIDS & COVID-19, particularly long COVID, share several significant similarities, especially in terms of viral persistence, T cell damage, immune system dysfunction, & activation of other pathogens. These parallels are important for understanding the long-term effects of both infections and their impact on the immune system…” A thread:
“In the blood of the long COVID patients, the team [at the University of Alberta] found higher levels of various proteins related to systemic inflammation—especially galectin-9 and artemin.. higher levels of galectin-9 in patients are associated with increased inflammation and brain fog.. higher levels of artemin are associated with widespread pain, more severe pain and cognitive impairment.. galectin-9 is shed by stressed neutrophils—the most abundant white blood cells—in long COVID patients. This released galectin-9 can promote chronic inflammation by affecting various immune cells.. long COVID dysregulates the production of red blood cells, which results in an abundance of immature red blood cells in the blood of these patients. Normally, immature red blood cells are present in the bone marrow but not in the blood of healthy people. It is these immature red blood cells in the blood that suppress the immune system and contribute to the elevation of artemin in the plasma of long-COVID patients."
“This is the 5th year of the pandemic in the Let It Rip Kingdom of Sweden. Everyone is constantly reinfected with the immune damaging SARS-CoV-2.
Respiratory virus/bacteria infections like Rhino/Enterovirus, Adenovirus, Mycoplasma pneumoniae or Pertussis are skyrocketing.
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“An important paper!
We keep focusing on Spike protein-only vaccines -> to our peril
It’s the 1 protein w the #1 MOST reasons to mutate!
Many parts of the virus also drive robust immune protection
Tmrws vaccines should focus on non-Spike to reduce variant immune evasion”
“Neither vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure.
The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs). “
“Neither (MRNA) vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure.
The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs).
All study participants had received between two to five doses of messenger RNA (mRNA) COVID-19 vaccines—which code for SARS-CoV-2’s spike—during the preceding 3 years.
“Long COVID’ affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.”
“Long COVID, or post-acute COVID syndrome (PACS), is now estimated to occur in 19% of adults having presented with COVID-19.. PACS is believed to be caused by immunological changes that persist after acute infection. Furthermore, it is now increasingly recognized that these changes include not only those in the adaptive immune system, such as production of autoantibodies or autoreactive T cells due to molecular mimicry, but also those in the innate immune system.. A new study by Cheong et al. in Cell reveals crucial differences in the transcriptional and epigenetic state of innate immune cells and their progenitors [among PASC patients].. the study team demonstrated that myeloid cells and hematopoietic progenitor cells harbored transcriptional and chromatin accessibility changes that did not return to baseline even 1 year after acute SARS-CoV-2 infection. These data provide powerful evidence that persistent changes (i.e., trained immunity) may underlie PACS..”
“Man given 12 months to live after headaches. It's glioblastoma.
@nypost will never share that CMV is airborne and causes glioblastoma.
90% of us have CMV. COVID dysregulates the immune system. So does CMV when reactivated.
COVID can reactivate CMV.”
“In a recent interview, Fauci puts the C19 herd immunity fantasy to bed once and for all. No such thing can ever be achieved, due to lack of immune response durability”
“There's a lot you can do to boost your immune system.
Getting sick isn't one of them.”
COVID more severe, longer-lasting than other respiratory diseases.
The findings support the histopathological evidence of an exuberant immune reaction associated with SARS-CoV-2 infection.
This is from 2021. We never heard about it again.
“As part of a new study on hybrid immunity to the virus, the large, multi-institution research team led by The University of Texas at Austin discovered and isolated a broadly neutralizing plasma antibody, called SC27, from a single patient. Using technology developed over several years of research into antibody response, the team led by UT engineers and scientists obtained the exact molecular sequence of the antibody, opening the possibility of manufacturing it on a larger scale for future treatments.”
Your immune system is a factory 🧵
T-cells are the essential workers.
SARS-CoV-2 -19 is a hacker that doesn't just disrupt operations from the outside.
It infiltrates the system and systematically lays off the workers (T-cells).
CO-INFECTION is the NEXT TIME BOMB 💥
SARS-CoV-2 + MYCOBACTERIUM TUBERCULOSIS (Mtb), Mtb which was before the pandemic, the leading infectious cause of death worldwide due to a single infectious agent
“Hey folks, ONE QUARTER of the global population (1.7 BILLION) carries the bacteria that causes tuberculosis (TB), Mycobacterium tuberculosis, in a dormant state. All it takes to activate >>> lowered immune functioning >>> SARS2.
Get it now?”
