exactly.
This is the #Leonardi_Effect
This is exactly what @NjbBari3 and I have been saying for 3 years.
A sustained CD 4 count of <500 will get you there. That's data from HIV positive people.
@dbdugger has the receipts. He too has been warning of this inevitably.
This is a direct result of immune suppression due to Covid infection. HIV does the same thing.
“As the Kansas and Missouri medical communities prepare for respiratory illness season, health officials grapple with an early COVID-19 infection spike and higher-than-normal tuberculosis infections in Wyandotte County.”
T cell exhaustion in #MECFS & #LongCovid from predominant sympathetic state & the T cells engage the sympathetic fibers & adrenergic signaling decreases their effector function. Sympathetic nerves suppress T-cell responses in infection and in cancer
"Molecular Trickery: How Covid Silently Sabotages the Human Immune System... Researchers have discovered that SARS-CoV-2 manipulates the human immune system by forcing cells to produce non-functional proteins, hindering the body’s antiviral defenses."
Study from California State University analyzed immune responses to 35 viruses using data from 219 datasets.
Findings show SARS-CoV-2 triggers a unique cytokine-chemokine profile, distinct from other viruses.
Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.
“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”
A grim reality for SARS-CoV-2 survivors
Severe and lasting damage to their immune systems
‘“Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era.’
In only 3 years we discovered this.
HIV, discovered in 1981? Took until the early 90s.
And yet, the @CDC_TB never tells people to avoid C0Vid.”
“Conclusion Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era. The immunosuppressive nature of the disease and its treatment modalities may contribute to post COVID-19 TB.”
T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses
This is YET ANOTHER study showing SARS-CoV-2 adversely impacts the immune system.
Monocyte abnormalities (decreases) were found in BOTH symptomatic and asymptomatic SARS-CoV-2 infections. Because monocytes INCREASE in normal immune response, this suggests monocyte infection.
Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.
Anecdote: "My absolute lymphocytes count is below 1 again. My lymphocytes subsets are as bad or worse as they were in 2020. Numbers had normalized in 2022 with Evusheld. So far as I know, I haven't been reinfected. It's not #HIV, but it's acquired immune deficiency. #LongCOVID #AIDS"
Case Study: I’ve got another, mid 60s. In hospital 3 times for FUO. Finally gets Dx coccidioidomycosis septicemia. COVID in February. Persistent lymphocytopenia since then. CD4/CD8 pending but pretty sure what it’s going to show. Worried how often this is going to happen.
Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe
