Detailed analysis on Twitter: Covid, Sars 2: Public Health Canada finally admits and warns about 'immune dysregulation' caused by the virus which could have 'significant impact on the incidence and associated burden of infectious diseases' in latest briefing and that reinfection increases chances of death
BA.5 has improved ability compared to BA.1 to 𝙨𝙪𝙥𝙥𝙧𝙚𝙨𝙨 𝙝𝙤𝙨𝙩 𝙞𝙢𝙢𝙪𝙣𝙚 𝙧𝙚𝙨𝙥𝙤𝙣𝙨𝙚𝙨.
Higher disease severity of BA.5 is 𝙣𝙤𝙩 𝙤𝙣𝙡𝙮 due to immune evasiveness, but also suppression of host immune responses.
Medical anecdote: Hey #LongCovid & #MedTwitter does low CD4 definitely mean immunodeficiency or can there be a number of factors? My results are pretty low (HIV levels), & I know this was just documented in a LC study ~ does this mean we’re experiencing immunodeficiency -or am I missing something?
Medical anecdote: Seeing a lot of lymphopenia (low CD4, CD8 white blood cells) in ER patients these days. Seems to be over represented in those getting admitted to hospital, mostly for reasons unrelated to Covid. Are any clinician colleagues seeing the same?
Medical anecdote: I'm no immunologist but a CD4 count < 500 increases your risk of opportunistic infections. At only 317, you're certainly immunocompromised. I'm so sorry; this is highly disturbing. Lymphocyte Subset panels should be ordered for all Long Covid sufferers.
This Science paper buries herd immunity.
Omicron is not a “natural booster”. It actually REDUCED immunity in past-infected triple-vaccinated people.
"Acquired Protein S deficiency commonly occurs in COVID-19, with variable contribution to thromboembolic occurrence... Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis. Acquired PS deficiency is a relatively common complication of infection with human immunodeficiency virus 1 (HIV-1), varicella, dengue, and SARS-CoV-2, all of which are associated with an increased risk of thrombosis."
Detailed analysis on Twitter: I have repeatedly said that a chronic SARS-Cov-2 infection is deserving of the same treatment protocol as that of a chronic HIV infection. Hopefully, this thread will finally result in that happening. While looking for Bugs Bunny in a damn rabbit hole, people are suffering.
Blood abnormalities found in people with Long Covid
Study implicates lack of key hormone, damage to immune cells, and reawakened viruses.
Papers that show continuing dysfunction in T-cells: In Long Covid patients: https://nature.com/articles/s41590-021-01113-x In severe Covid-19 disease: https://nature.com/articles/s41418-022-00936-x Precipitates EBV reactivation: https://doi.org/10.1016/j.cell.2022.01.014 Seen in lung damage on autopsy studies:
Expert anecdote: This doctor’s T-cells are way below normal on 5 different T-cell parameters after being #COVID19 infected 5 times! Several studies have found T cell suppression/damage after COVID.
T cell counts of AIDS and COVID19 patients.
"The total absolute numbers of T cells and, in particular of the CD8+ subpopulation, are LOWER in COVID-19 patients compared to AIDS ones, while the CD4+ are reduced in both at similar levels"
Detailed analysis thread on Twitter: People keep asking me if sars cov 2 could alter T cell function to other pathogens and tagging me
Absolutely
And we need to look at T cell "exhaustion" 1/6
A timely and comprehensive review on the unclear contribution of T cells in protecting against SARS-COV-2 disease
The abstract reflects my impressions well. Despite efforts there's poor evidence T cell responses do more than mop up.
SARS Cov 2 has many redundant ways of hiding from cd8 T cells
Did not expect so many!
So the T cells are at a disadvantage
Excellent, detailed analysis by Dr. Akiko Iwasaki on Twitter: In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵
