Covid and the Immune System

Covid and the Immune System

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I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.

Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.

“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”

#AIDS#lymphopenia#T-cells#Immune system
·x.com·
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
“I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency. #AIDS #longCOVID “
#AIDS#lympocytopenia#Immune system
·x.com·
I've had lymphocytopenia from COVID since March 2020. My T and B cells are low. I catch infections easily; latent infections reactivate. Spike protein & continued + RAT tests point to viral persistence. This is acquired immune deficiency.
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Covid causes long-term reduction of immune system cells." Significantly, researchers found those infected (who had mild symptoms) had similar immune function to the non-infected group 10 weeks post-covid, but much reduced immune function at 10 months
#Immune system
·onlinelibrary.wiley.com·
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19

A grim reality for SARS-CoV-2 survivors

Severe and lasting damage to their immune systems

·onlinelibrary.wiley.com·
Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."

‘“Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era.’

In only 3 years we discovered this.

HIV, discovered in 1981? Took until the early 90s.

And yet, the @CDC_TB never tells people to avoid C0Vid.”

#Tuberculosis after Covid
·x.com·
"Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era."
Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports | PLOS ONE
Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports | PLOS ONE

“Conclusion Tuberculosis after recovering from COVID-19 is becoming more common, potentially leading to a TB outbreak in the post-COVID-19 era. The immunosuppressive nature of the disease and its treatment modalities may contribute to post COVID-19 TB.”

#Tuberculosis after Covid#Tuberculosis#another potential pabdemic?#immune dysregulation#Immune system#opportunistic infections
·journals.plos.org·
Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports | PLOS ONE
A T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses
A T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses

T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses

This is YET ANOTHER study showing SARS-CoV-2 adversely impacts the immune system.

Monocyte abnormalities (decreases) were found in BOTH symptomatic and asymptomatic SARS-CoV-2 infections. Because monocytes INCREASE in normal immune response, this suggests monocyte infection.

·mdpi.com·
A T-Cell-Derived 3-Gene Signature Distinguishes SARS-CoV-2 from Common Respiratory Viruses
COVID's Hidden Toll: Full-Body Scans Reveal Long-Term Immune Effects
COVID's Hidden Toll: Full-Body Scans Reveal Long-Term Immune Effects
“The lingering toll the SARS-CoV-2 virus exacts on the immune system is widespread and hiding in plain sight”
The lingering toll the SARS-CoV-2 virus exacts on the immune system is widespread and hiding in plain sight,
·sciencealert.com·
COVID's Hidden Toll: Full-Body Scans Reveal Long-Term Immune Effects
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
A NEW study shows that cells infected with SARS-CoV-2 downregulate important immune signals known as NKG2D ligands. These ligands play a crucial role in activating the immune system, particularly natural killer (NK) cells, which are central to fighting viral infections.
·cell.com·
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
John Hess MD on Twitter
John Hess MD on Twitter

Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.

#Immune system#T-cells
·twitter.com·
John Hess MD on Twitter
COVID-19: Study Suggests Long-term Damage to Immune System
COVID-19: Study Suggests Long-term Damage to Immune System
"findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
#Immune system#T-cells
·infectioncontroltoday.com·
COVID-19: Study Suggests Long-term Damage to Immune System
Amy Mitchell on Twitter
Amy Mitchell on Twitter

Anecdote: "My absolute lymphocytes count is below 1 again. My lymphocytes subsets are as bad or worse as they were in 2020. Numbers had normalized in 2022 with Evusheld. So far as I know, I haven't been reinfected. It's not #HIV, but it's acquired immune deficiency. #LongCOVID #AIDS"

#Long Covid#Immune system
·twitter.com·
Amy Mitchell on Twitter
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: I’ve got another, mid 60s. In hospital 3 times for FUO. Finally gets Dx coccidioidomycosis septicemia. COVID in February. Persistent lymphocytopenia since then. CD4/CD8 pending but pretty sure what it’s going to show. Worried how often this is going to happen.

#Immune system#lympocytopenia
·twitter.com·
John Hess MD on Twitter
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe

#Immune system#opportunistic infections#T-cells
·twitter.com·
John Hess MD on Twitter
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
#T-cells#opportunistic infections#Immune system
·academic.oup.com·
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Pnas
Pnas
"Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants"
#Immune system
·pnas.org·
Pnas
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?

From Sept. 2022: "...what impacts has COVID had on your overall immune system?

It’s early days yet. But growing evidence suggests there are changes to your immune system that may put you at risk of other infectious diseases.

Here’s what we know so far:

#Immune system#reinfection#opportunistic infections
·theconversation.com·
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?
Pnas
Pnas

Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?

  • Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
#Immune system#T-cells
·pnas.org·
Pnas
T. Ryan Gregory on Twitter
T. Ryan Gregory on Twitter

Detailed analysis thread of what we know so far about Covid and the immune system: You'd have to ignore a lot of research to say that SARS-CoV-2 infection has no effect on the immune system. So the scientific debate is about how severe, how often, for how long, how much more likely with repeated infections, and how it would manifest in different people.

#Immune system
·twitter.com·
T. Ryan Gregory on Twitter
laurie allee on Twitter
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
#Immune system#T-cells#reinfection
·twitter.com·
laurie allee on Twitter