Covid and the Immune System

Covid and the Immune System

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Pnas
Pnas

Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?

  • Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
#Immune system#T-cells
·pnas.org·
Pnas
T. Ryan Gregory on Twitter
T. Ryan Gregory on Twitter

Detailed analysis thread of what we know so far about Covid and the immune system: You'd have to ignore a lot of research to say that SARS-CoV-2 infection has no effect on the immune system. So the scientific debate is about how severe, how often, for how long, how much more likely with repeated infections, and how it would manifest in different people.

#Immune system
·twitter.com·
T. Ryan Gregory on Twitter
laurie allee on Twitter
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
#Immune system#T-cells#reinfection
·twitter.com·
laurie allee on Twitter
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
"Analyses of patients have revealed marked dysregulation of the immune system in severe cases of human coronavirus infection, and there is ample evidence that aberrant immune responses to human coronaviruses are typified by impaired induction of..."
·nature.com·
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
#Kids#Immune system#T-cells
·sciencedirect.com·
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19