Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection:
Covid and the Immune System
Anthony J Leonardi, MBBS, PhD on Twitter
Detailed analysis thread on Twitter: People keep asking me if sars cov 2 could alter T cell function to other pathogens and tagging me
Absolutely
And we need to look at T cell "exhaustion" 1/6
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast? - PubMed
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?
Michael Lin, MD PhD 🧬 on Twitter
A timely and comprehensive review on the unclear contribution of T cells in protecting against SARS-COV-2 disease
The abstract reflects my impressions well. Despite efforts there's poor evidence T cell responses do more than mop up.
Anthony J Leonardi, MBBS, PhD on Twitter
SARS Cov 2 has many redundant ways of hiding from cd8 T cells
Did not expect so many!
So the T cells are at a disadvantage
Prof. Akiko Iwasaki on Twitter
Excellent, detailed analysis by Dr. Akiko Iwasaki on Twitter: In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵
Pnas
A previous study showed that SARS-CoV-2 (ancestral) induced MHC I down-regulation in infected cells. They found a key role of ORF8 in this process.
MHC class I antigen presentation: learning from viral evasion strategies - PubMed
CD8 T cells help fight off viral infection by detecting and killing infected cells. CD8 T cells detect MHC I + viral peptide on infected cells. One of the common tricks viruses use to avoid killing is to inhibit MHC I expression and presentation.
Chris Turnbull on Twitter
Detailed thread on Twitter: Impressive new study finds Sars Cov 2 has immune suppressive abilities comparable to HIV and that variants increase virus abilities to stop vital anti-viral mechanism in the immune system
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health
"...persistent T cell abnormalities in convalescent COVID-19 patients more than three months after initial infection. These changes are more marked with age and are independent of ongoing subjective ill-health, fatigue and reduced exercise tolerance."
Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System
Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System
Kashif Pirzada, MD on Twitter
Detailed discussion on Twitter: I've gone over in detail with an immunologist just some of the immune system/T-cell problems SARS2 creates, which cause severe disease and possibly Long Covid. Vaccines surely help reduce this, perhaps by half, but do not eliminate the risk completely:
T cell apoptosis characterizes severe Covid-19 disease
"Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis."
Dr Satoshi Akima FRACP 『秋間聰』 on Twitter
Lymphocyte exhaustion may persist after recovery from COVID, especially depletion of naive T-cells that are protective of overexuberant cytotoxic T-cell driven responses. This may set up the stage for even more overexuberant T-cell response in future reinfections
Ccr3
"This is the first report of COVID-19 in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier. HTLV-1 infection can cause immune dysfunction even in asymptomatic carriers."
COVID‐19 in a human T‐cell lymphotropic virus type‐1 carrier
SARS News Network (SNN) 🦠 😷 on Twitter
Detailed thread on Twitter: T CELL APOPTOSIS VIA COVID-19: Bombshell new study, done by an elite group of doctors such as @fitterhappierAJ , has found that severity of the disease is correlated to T-cell apoptosis, essentially, your T-cells are contributing to your demise. Very detailed stuff here.
COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: A case report
“This case appears to confirm the concerns that the CD4+ T-cell depletion associated with COVID-19 may promote the development of active tuberculosis from latent infection much like HIV does.”
Eric Feigl-Ding on Twitter
Comprehensive thread on Twitter: Listen up—Top 🇬🇧 scientists warns that “In the last week—there’s now evidence that T-cells…get damaged the same way that HIV and other RNA-virus damage T-cell immunity”. ➡️Prof Costello ( @globalhlthtwit ) raises serious concerns on #COVID19 & the 🧠—a🧵:
Anthony J Leonardi, MBBS, PhD on Twitter
Interesting. Uchicago finds in a preprint a strong signature of T cell apoptosis in Covid- more than HIV, and a loss of naive T cells
I wrote about t cell apoptosis and a loss of naive T cells in frontiers in 2020 as being problematic