“A possible new diagnostic approach to Long COVID. Long COVID may involve microcirculatory blockages - tiny, persistent clots known as fibrinaloid microclots. These abnormal fibrin structures resist breakdown and can obstruct blood flow in the smallest vessels.🧵”
“COVID-19 doesn’t just cause inflammation. It switches off the genes that repair blood vessels - and switches on those that drive inflammation and destruction. And what’s worse - this state lasts for at least six months, long after the infection is gone🧵”
“Our findings corroborate and expand upon existing evidence of endothelial dysfunction in COVID-19 patients, demonstrating decreased angiogenesis capacity, increased apoptosis, and oxidative stress."
“This confirms persistent endothelial damage after recovery”
Stellenbosch University and Montpellier researchers studied 50 Long COVID patients and found their blood carried far more microclots tied to neutrophil immune traps.
These sticky structures may stabilize clots and help explain persistent symptoms.
Researchers from 16 different countries recruited 2390 individuals (age 50 ± 15 years, 49.2% women) to assess the impacts of COVID-19 on vascular aging.
They found that persistent COVID-19 symptoms in women correlated with increased vascular aging.
Covid accelerates vascular aging An 18-country, 38-center study of ~2,000 participants —Effect predominantly in women, adding 5 years of vascular aging (EVA) —Seen with non-hospitalized and mild-moderate Covid
A new study shows that adding SARS-CoV-2’s main protease (Mpro) enzyme to plasma from healthy donors can trigger blood clots by activating coagulation factors VII and XII.
This may explain Covid’s common blood clot risk.
“SARS-CoV-2 hijacks the clotting system of your body for its own purposes.
The spike protein binds to fibrin, rendering it toxic. Those toxic fibrin proteins damage blood vessel walls and drive an inflammatory response.
Other viruses don't do this.”
Researchers at the University of Virginia found that some COVID-19 survivors produce antibodies that mimic ACE2 enzyme activity.
These may disrupt blood pressure regulation and contribute to Long COVID symptoms.
The science of this Aug 2024 paper about #Covid was known clinically in Jan 2020 (attached paper).
If doctors had just read the literature & altered their treatment, millions of people would not have died.
When fibrin is being formed in the body a protein called D-dimer is made and can be measured in a blood sample.
This paper first published January 30, 2000 found D-dimer increased in 36% of patients, the sickest.
“I’ve never seen patients in their 20’s and 30’s with DVT’s until the past few years. It’s unspeakably messed up.
Not too long ago, saw yet another, this time un-vax’d.
@RandPaul End gain of function and have Nuremberg trials for the sociopaths who did this.”
