Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging
Thread by @ZdenekVrozina on Thread Reader App
“A possible new diagnostic approach to Long COVID. Long COVID may involve microcirculatory blockages - tiny, persistent clots known as fibrinaloid microclots. These abnormal fibrin structures resist breakdown and can obstruct blood flow in the smallest vessels.🧵”
Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients
Stellenbosch University and Montpellier researchers studied 50 Long COVID patients and found their blood carried far more microclots tied to neutrophil immune traps.
These sticky structures may stabilize clots and help explain persistent symptoms.
COVID Isn’t a Cold. It’s Cigarettes All Over Again
“People are catching this thing two, three times a year and acting like it’s nothing. Just a cold. Just the sniffles. Meanwhile, their blood vessels are getting shredded”
Vascular Aging May Explain Long COVID's Predominance in Women
Researchers from 16 different countries recruited 2390 individuals (age 50 ± 15 years, 49.2% women) to assess the impacts of COVID-19 on vascular aging.
They found that persistent COVID-19 symptoms in women correlated with increased vascular aging.
pendingpublications
Covid accelerates vascular aging An 18-country, 38-center study of ~2,000 participants —Effect predominantly in women, adding 5 years of vascular aging (EVA) —Seen with non-hospitalized and mild-moderate Covid
Is Covid-19 a disease of the blood vessels?
“Dr Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system, and the research that is trying to tackle it.”
Dr Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system, and the research that is trying to tackle it.
Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis - BMC Medicine
In a review of 37 studies, encompassing 2,965,467 patients, 15% of Covid survivors suffered from cardiovascular sequelae.
SARS-CoV-2 Infection Association with Atherosclerotic Plaque Progression at Coronary CT Angiography and Adverse Cardiovascular Events | Radiology
“Covid associated with acceleration of coronary atherosclerosis and developing high-risk plague, adverse cardiovascular events, by serial CCTA in over 800 participants and controls.”
COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds
“COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds”
COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds
COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds
“COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds”
COVID-19 raises the stakes for heart attacks, strokes, and even death long after infection, new study finds
The Cardiac pathophysiology of Covid-19
“Findings emphasize that Covid-19’s myocardial pathology predominantly arises from fibrin thrombi within the coronary MICROVASCULAR network, especially in the abluminal spaces.
➡️This pathological process leads to myocardial fibre injury, necrosis, and ischemic changes( = fibrosis), contributing to both the acute symptoms and long-term sequelae (Long Covid).”
The uptick in avascular necrosis (AVN) cases of the hip after COVID-19 is a serious development that's got the medical community buzzing.
Uptick in post-acute Covid avascular necrosis.
Just like what happened in SARS1 survivors, which was well-documented but our government chose to ignore and pretend Covid is a cold.
COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type | Arteriosclerosis, Thrombosis, and Vascular Biology
“COVID-19 at all levels of severity was associated with significantly higher risk of MI, stroke, or all-cause mortality over 1003 days of follow-up."
How Long COVID Research Could Change the Way We Think About Blood Microclots
“‘I couldn't believe what I saw; these amyloid signals were everywhere. And I got back to the control sample and did the same, and I saw little bits, but not much.’
Pretorius had become one of the first in the world to discover that COVID-19 could induce widespread clotting in the blood of patients.”
. “I couldn't believe what I saw; these amyloid signals were everywhere. And I got back to the control sample and did the same, and I saw little bits, but not much.”Pretorius had become one of the first in the world to discover that COVID-19 could induce widespread clotting in the blood of patients.
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Long Covid patients exhibited persistent endothelial dysfunction.
This was indicated by lower venular flicker-induced dilation (vFID), narrower central retinal artery equivalent (CRAE), and lower arteriolar-venular ratio (AVR).
“Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients.”
How Long COVID Research Could Change the Way We Think About Blood Microclots
“This observation seemingly confirmed a biomolecular link between the immediate symptoms experienced by acute COVID patients and the lingering symptoms of those with long COVID”
This observation seemingly confirmed a biomolecular link between the immediate symptoms experienced by acute COVID patients and the lingering symptoms of those with long COVID
Unraveling Covid’s Pernicious Role in Brain Fog and Clotting
“Navigating social distancing requirements that complicated lab work, Akassoglou and her collaborators conducted a series of experiments in mice to explore the pernicious role of the coronavirus’s spike protein.
They discovered that beyond serving as the virus’s “key” to enter cells, spike binds with a blood clotting factor called fibrinogen, creating structurally abnormal, inflammation-promoting clumps of fibrin — the insoluble material that forms the mesh-like structures essential for wound healing.
High levels of these abnormal clots not only push the body’s clotting system into overdrive, increasing clot formation and inflammation, but also suppress natural killer cells — the immune system’s virus-clearing soldiers.”
Navigating social distancing requirements that complicated lab work, Akassoglou and her collaborators conducted a series of experiments in mice to explore the pernicious role of the coronavirus’s spike protein. They discovered that beyond serving as the virus’s “key” to enter cells, spike binds with a blood clotting factor called fibrinogen, creating structurally abnormal, inflammation-promoting clumps of fibrin — the insoluble material that forms the mesh-like structures essential for wound healing. High levels of these abnormal clots not only push the body’s clotting system into overdrive, increasing clot formation and inflammation, but also suppress natural killer cells — the immune system’s virus-clearing soldiers.
Thieme E-Books & E-Journals -
“Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook”
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook
Post-acute COVID-19 syndrome: prevalence of peripheral microvascular endothelial dysfunction and associations with NT-proBNP dynamics
In highly symptomatic #LongCOVID adults, 41% have objectively measurable microvascular dysfunction.
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Great analysis thread:
“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’
Simplified breakdown of the paper below!
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
“In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.”
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management
"The COVID-19 thrombus has unique and distinct characteristics."
Thrombosis in acute and #LongCovid
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Abilities Research Center on Twitter
Long Covid and blood clotting
Mike Hoerger, PhD MSCR MBA on Twitter
"I hope to god I'm wrong. I've never wanted to be more wrong in my life.... Worst case scenario... we are going to see a tsunami of cardiovascular disease over the next few decades." #LongCOVID
Persistent capillary rarefication in long COVID syndrome
"current data strongly suggest that COVID-19 leaves a persistent capillary rarefication even 18 months after infection. Whether, to what extent, and when the observed damage might be reversible remains unclear. If capillary rarefaction were to persist..."
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin - Cardiovascular Diabetology
"Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin"
Expert’s warning as nearly one in four Covid patients show signs of blood clotting a year later
"Up to a quarter of patients discharged from hospital after Covid-19 treatment are still showing “unusual” blood clotting activity up to one year later."