“NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
Turns out that Mpro, a viral protease [pro-tee-ace], can START the cascade.
a thread written for everyone:
Here's the takeaway: The Main protease (Mpro) of SARS-CoV-2—an enzyme that cuts up viral polyproteins—can also cleave a few host coagulation factors in a way that ACTIVATES them and BEGINS the blood clot cascade.”
Great analysis thread:
“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’
Simplified breakdown of the paper below!
“COVID-19, caused by the SARS-CoV-2 virus is an acquired thrombophila with a high incidence of thrombosis.
“Thrombosis…can involve most organs and organ systems.”
Thread by @DickZoutman on Thread Reader App
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Related: "Blood thinners and COVID: The findings guiding patient care"
From 2021: "Blood clot risk from coronavirus infection outweighs risk from vaccine: study
This is the largest study to date, covering almost 30 million people."
From 2022--largely ignored/unknown by clinicians: “There are also manifestations of people having an increased risk of blood clots during and after COVID-19..."
Analysis thread on Twitter Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
Even mild Covid can increase your chance of blood clots after the initial infection. *all images available as editable, printable files, DM for info.
"I hope to god I'm wrong. I've never wanted to be more wrong in my life.... Worst case scenario... we are going to see a tsunami of cardiovascular disease over the next few decades." #LongCOVID
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State "complications of COVID-19 are caused by blood hyperviscosity driven by marked hyperfibrinogenemia. This results in a distinctive hyperviscosity syndrome...A change in blood viscosity causes a threefold inverse change in blood flow..."