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The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
#blood clots#coagulopathy#fibrin#cytokines#Mpro#vascular#Endothelium
·biorxiv.org·
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.

“NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.

Turns out that Mpro, a viral protease [pro-tee-ace], can START the cascade.

a thread written for everyone:

Here's the takeaway: The Main protease (Mpro) of SARS-CoV-2—an enzyme that cuts up viral polyproteins—can also cleave a few host coagulation factors in a way that ACTIVATES them and BEGINS the blood clot cascade.”

#blood clots#vascular#Mpro#Discussion#bradykinin#thrombin#coagulopathy
·x.com·
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Great analysis thread:

“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’

Simplified breakdown of the paper below!

#fibrin#blood clots#Endothelium#thromboinflammation#neuropathology#brain#brain injury#long covid#Neuroinflammation#inflammation#Viral Persistence#Immune system
·x.com·
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
“In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.”
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
#vascular#blood clots#plasma alterations#long covid
·molmed.biomedcentral.com·
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Harriet Carroll: Recognise vax-induced long COVID on Twitter

Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots

#Long Covid#Clots#blood clots#microclots#vascular#Endothelium#vasculitis
·twitter.com·
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
"Study shows that COVID-19, unlike other viruses, seems to impact the heart's small blood vessels...Chemical staining tests revealed blood clotting in the small blood vessels of the heart tissue. These fibrous blood clots may remain even after the virus is gone"
#Clots#blood clots#vascular#Heart
·newsnetwork.mayoclinic.org·
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
laurie allee on Twitter
laurie allee on Twitter
"study led by University at Buffalo confirmed...COVID-19 vaccines pose only trivial risk of venous thromboembolism (VTE), or blood clots. In addition, the study found that becoming infected with COVID-19 poses a significant risk of blood clots."
#Clots#blood clots#Deep Vein Thrombosis#vascular
·twitter.com·
laurie allee on Twitter
Jbm
Jbm
SARS‐CoV‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks: effects specific to SARS-CoV-2, vascular dysfunction caused by an increase in inflammatory cytokines, dexamethasone prevents spike protein-induced ED.
#vascular#Clots#blood clots#Endothelium
·onlinelibrary.wiley.com·
Jbm
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
"Elevated D-dimer levels are a predictor of hypercoagulation complications in COVID-19. Patients with persistently elevated D-dimer levels after recovery from COVID-19 should be screened for thromboembolic complications, even if they are asymptomatic."
#D-dimer#blood clots#Clots#vascular#Endothelium#pulmonary embolism
·cureus.com·
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
Even a mild case of COVID can put you at higher risk for blood clots and death, according to a new study
Even a mild case of COVID can put you at higher risk for blood clots and death, according to a new study
"...individuals who had been diagnosed with COVID but weren’t hospitalized were still at a risk nearly 3 times as high for venous thromboembolism—blood clots & pulmonary embolism—when compared with similar individuals who hadn’t had COVID."
#vascular#blood clots#Clots#pulmonary embolism#Deep Vein Thrombosis
·news.yahoo.com·
Even a mild case of COVID can put you at higher risk for blood clots and death, according to a new study
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State

COVID-19 Demonstrates That Inflammation Is a Hyperviscous State "complications of COVID-19 are caused by blood hyperviscosity driven by marked hyperfibrinogenemia. This results in a distinctive hyperviscosity syndrome...A change in blood viscosity causes a threefold inverse change in blood flow..."

#blood clots#Clots#vascular
·cureus.com·
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State