Found 19 bookmarks
Newest
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
#blood clots#coagulopathy#fibrin#cytokines#Mpro#vascular#Endothelium
·biorxiv.org·
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Great analysis thread:

“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’

Simplified breakdown of the paper below!

#fibrin#blood clots#Endothelium#thromboinflammation#neuropathology#brain#brain injury#long covid#Neuroinflammation#inflammation#Viral Persistence#Immune system
·x.com·
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Harriet Carroll: Recognise vax-induced long COVID on Twitter

Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots

#Long Covid#Clots#blood clots#microclots#vascular#Endothelium#vasculitis
·twitter.com·
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Jbm
Jbm
SARS‐CoV‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks: effects specific to SARS-CoV-2, vascular dysfunction caused by an increase in inflammatory cytokines, dexamethasone prevents spike protein-induced ED.
#vascular#Clots#blood clots#Endothelium
·onlinelibrary.wiley.com·
Jbm
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
"Elevated D-dimer levels are a predictor of hypercoagulation complications in COVID-19. Patients with persistently elevated D-dimer levels after recovery from COVID-19 should be screened for thromboembolic complications, even if they are asymptomatic."
#D-dimer#blood clots#Clots#vascular#Endothelium#pulmonary embolism
·cureus.com·
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed

From 2020: "COVID-19 can be considered a vascular disease with regards to serious complications and causes of mortality...blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19."

#Clots#vascular#blood clots#Endothelium
·pubmed.ncbi.nlm.nih.gov·
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
The big concern raised by this fresh study is that medium- to long-term harms on the body’s blood vessel network (the vascular system) may be much more common than that. And it could drive a new pandemic of cardiovascular disease over the coming years."
#Heart#Stroke#Endothelium#vascular#Clots#blood clots#pulmonary embolism#Deep Vein Thrombosis
·iol.co.za·
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
#Long Covid#female#estrogen#Clots#blood clots#Heart#vascular#Endothelium
·authorea.com·
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
More evidence that LongCOVID symptoms are due to widespread endothelial damage and a failed fibrinolytic system. We again found numerous entrapped inflammatory molecules; and this time also antibodies in microclots
#Clots#microclots#vascular#Endothelium#blood clots
·cardiab.biomedcentral.com·
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
"Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury."
#Endothelium#lung#vascular#Clots#blood clots
·frontiersin.org·
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress