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Thread by @ZdenekVrozina on Thread Reader App
Thread by @ZdenekVrozina on Thread Reader App

“A possible new diagnostic approach to Long COVID. Long COVID may involve microcirculatory blockages - tiny, persistent clots known as fibrinaloid microclots. These abnormal fibrin structures resist breakdown and can obstruct blood flow in the smallest vessels.🧵”

#blood clots#microclots#Long Covid#vascular#fibrin#microcirculation#thromboinflammation#thrombotic endotheliitis#Clots#inflammation#analysis#Discussion
·threadreaderapp.com·
Thread by @ZdenekVrozina on Thread Reader App
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
#blood clots#coagulopathy#fibrin#cytokines#Mpro#vascular#Endothelium
·biorxiv.org·
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Great analysis thread:

“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’

Simplified breakdown of the paper below!

#fibrin#blood clots#Endothelium#thromboinflammation#neuropathology#brain#brain injury#long covid#Neuroinflammation#inflammation#Viral Persistence#Immune system
·x.com·
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!