“Findings emphasize that Covid-19’s myocardial pathology predominantly arises from fibrin thrombi within the coronary MICROVASCULAR network, especially in the abluminal spaces.
➡️This pathological process leads to myocardial fibre injury, necrosis, and ischemic changes( = fibrosis), contributing to both the acute symptoms and long-term sequelae (Long Covid).”
“Navigating social distancing requirements that complicated lab work, Akassoglou and her collaborators conducted a series of experiments in mice to explore the pernicious role of the coronavirus’s spike protein.
They discovered that beyond serving as the virus’s “key” to enter cells, spike binds with a blood clotting factor called fibrinogen, creating structurally abnormal, inflammation-promoting clumps of fibrin — the insoluble material that forms the mesh-like structures essential for wound healing.
High levels of these abnormal clots not only push the body’s clotting system into overdrive, increasing clot formation and inflammation, but also suppress natural killer cells — the immune system’s virus-clearing soldiers.”
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
"I hope to god I'm wrong. I've never wanted to be more wrong in my life.... Worst case scenario... we are going to see a tsunami of cardiovascular disease over the next few decades." #LongCOVID
Patient Anecdote thread on Twitter: Today I travelled 4000miles to get tested for Microclots to test the theory that this is causing my #longcovid symptoms. Turns out I have them. This testing needs to be made accessible to all those suffering around the world so they can be treated (1)
Detailed analysis thread on Twitter: 1/🧵 Micro Clots & Endothelial Dysfunction in Long COVID
Plus new Epidemiology in @JAMA_current some say proves #LongCOVID is a hoax⁉️
Truth is…endothelial dysfunction plus inflammation can lead to life-altering brain & body dz.
Let’s explore data
“One core question is: Do these microclots actually represent a root cause, or are they in response to something else that's ongoing?” says Michael VanElzakker PhD, co-founder of PolyBio Research Foundation, which is focused on studying viral reservoir:
Tiny, Menacing Microclots May Explain Long COVID’s Symptoms
Anecdote: Big news: I was lucky to get tested for micro blood clots, & I have a lot of them! #LongCovid
Healthy control blood on the left. Mine on the right. The green is all microclots!
These clots are likely blocking oxygen from getting around my body & could explain many symptoms. 1/
Related The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Develop an accessible, lab-based method to diagnose microclots in LongCovid patients Millions suffering from LongCovid don't have access to a regular test for diagnosis. Top researchers develop a widely available method to help explain the condition's debilitating symptoms.
