The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
“NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
Turns out that Mpro, a viral protease [pro-tee-ace], can START the cascade.
a thread written for everyone:
Here's the takeaway: The Main protease (Mpro) of SARS-CoV-2—an enzyme that cuts up viral polyproteins—can also cleave a few host coagulation factors in a way that ACTIVATES them and BEGINS the blood clot cascade.”
Long COVID: pathophysiological factors and abnormalities of coagulation - PubMed
Fibrinogen can turn amyloid in presence of spike protein. We refer to it as microclots, driving widespread endothelialitis. Note C&D) examples of clots from COVID; E&F) healthy clot formed with spike Overview:
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Japan study: 65 million+ participants shows role of endothelial dysfunction in #longCOVID and leading to a potential chronic kidney disease and cardiovascular damage/disease.
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Great analysis thread:
“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’
Simplified breakdown of the paper below!
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
“In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.”
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
“With regard to COVID, terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to paint a portrait that lulls the reader into a false sense of security, drawing comparisons between a virus that has been around for less than five years to other viruses or conditions with respect to which the audience has grown familiar with. Moreover, even stock photos selected for certain news articles can subtly influence your response to the content expressed in that piece. A selected photo of a person gently cradling a tissue paper over their nose, instead of a person waiting for treatment in the ER, may give off the impression that they are harmlessly recovering from a tear-jerking soap opera instead of from a viral illness. In fact, we want to believe that COVID-19 is as gentle as a cold, as this outcome is far more pleasing, so this skewed presentation of the risk is far more palatable than what is expressed in the scientific literature.”
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
"The selection of words modulates the message...terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to...lull the reader into a false sense of security... COVID-19 is not primarily a respiratory infection. This virus can cause a systemic disease with far-reaching effects on the body, particularly blood vessels. Once SARS-CoV-2 enters the body, the virus can affect the ...blood vessels, causing inflammation and damage.
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Your Risk of Blood Clots Is High for the First Year After You Have COVID-19, Study Suggests
"the virus can ramp up your risk of developing blood clots—and that risk stays higher than normal for a year afterward...study analyzed data from 48 million people from January 2020 until day before COVID-19 vaccines were made available in December 2020."
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.
"The longer the period from COVID-19 infection the worse the vascular impairment...."
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