Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy
Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy
Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
“In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.”
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management
"The COVID-19 thrombus has unique and distinct characteristics."
Thrombosis in acute and #LongCovid
Thread by @DickZoutman on Thread Reader App
“COVID-19, caused by the SARS-CoV-2 virus is an acquired thrombophila with a high incidence of thrombosis.
“Thrombosis…can involve most organs and organ systems.”
Thread by @DickZoutman on Thread Reader App
Tirofiban prevents the effects of SARS-CoV-2 spike protein on macrophage activation and endothelial cell death
Study in Italy: Tirofiban was found to prevent the pro-inflammatory effects of SARS-CoV-2 spike protein on macrophages and reduce endothelial cell death.
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
“With regard to COVID, terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to paint a portrait that lulls the reader into a false sense of security, drawing comparisons between a virus that has been around for less than five years to other viruses or conditions with respect to which the audience has grown familiar with. Moreover, even stock photos selected for certain news articles can subtly influence your response to the content expressed in that piece. A selected photo of a person gently cradling a tissue paper over their nose, instead of a person waiting for treatment in the ER, may give off the impression that they are harmlessly recovering from a tear-jerking soap opera instead of from a viral illness. In fact, we want to believe that COVID-19 is as gentle as a cold, as this outcome is far more pleasing, so this skewed presentation of the risk is far more palatable than what is expressed in the scientific literature.”
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
"The selection of words modulates the message...terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to...lull the reader into a false sense of security... COVID-19 is not primarily a respiratory infection. This virus can cause a systemic disease with far-reaching effects on the body, particularly blood vessels. Once SARS-CoV-2 enters the body, the virus can affect the ...blood vessels, causing inflammation and damage.
Vascular Inflammation in Neuropsychiatric Long Covid
Just been invited by a major journal to write a review on the imaging of
It is NOT a pneumonia or pneumonitis It is an immunothrombotic vasculopathy (inflammatory clotting disease)
SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease
Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease
COVID, heart disease and stroke
"COVID damages preferentially the inner linings of the blood vessels. That’s why you might hear COVID called a vascular disease — vascular means anything related to the blood vessels."
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Retinal Abnormalities and COVID
"Retinal microvascular abnormalities and impaired blood flow appear to be emerging as signature ocular manifestations of COVID-19 infections, researchers have found..."
Your Risk of Blood Clots Is High for the First Year After You Have COVID-19, Study Suggests
"the virus can ramp up your risk of developing blood clots—and that risk stays higher than normal for a year afterward...study analyzed data from 48 million people from January 2020 until day before COVID-19 vaccines were made available in December 2020."
Alarm over rise in blood clot deaths as charity calls on NHS to publish data
Alarm in rise of blood clot deaths in UK: "Vital information gathered about a serious condition is still not being published three years after the start of the Covid-19 pandemic, a charity has said."
Blood thinners and COVID: The findings guiding patient care
Related: "Blood thinners and COVID: The findings guiding patient care"
Study refutes COVID anti-vax blood clot claims
"study confirmed...vaccines pose only trivial risk of venous thromboembolism (VTE), or blood clots. In addition, the study found that becoming infected with COVID-19 poses a significant risk of blood clots."
Blood clot risk from coronavirus infection outweighs risk from vaccine study
From 2021: "Blood clot risk from coronavirus infection outweighs risk from vaccine: study
This is the largest study to date, covering almost 30 million people."
Abilities Research Center on Twitter
Long Covid and blood clotting
CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
Known since 2020: "CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity"
Risk for First-Time Clot Events Raised After COVID-19 Diagnosis - Physician's Weekly
Risk for First-Time Clot Events Raised After COVID-19 Diagnosis
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.
"The longer the period from COVID-19 infection the worse the vascular impairment...."
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New Guidelines Explain How to Manage Post-COVID Heart Problems
From 2022--largely ignored/unknown by clinicians: “There are also manifestations of people having an increased risk of blood clots during and after COVID-19..."
A Case of COVID-19-Induced Immune Thrombocytopenia (ITP) in an Adult Female: An Under-Recognized Emerging Phenomenon
A Case of COVID-19-Induced Immune Thrombocytopenia (ITP) in an Adult Female: An Under-Recognized Emerging Phenomenon
Emmanuel on Twitter
ENDOTHELIAL dysfunction in COVID-19 infections may lead to CARDIOVASCULAR COMPLICATIONS. "Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients" https://ijbs.com/v19p1664.htm *ECFC (endothelial colony forming cells)
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
"Study shows that COVID-19, unlike other viruses, seems to impact the heart's small blood vessels...Chemical staining tests revealed blood clotting in the small blood vessels of the heart tissue. These fibrous blood clots may remain even after the virus is gone"
laurie allee on Twitter
"study led by University at Buffalo confirmed...COVID-19 vaccines pose only trivial risk of venous thromboembolism (VTE), or blood clots. In addition, the study found that becoming infected with COVID-19 poses a significant risk of blood clots."
laurie allee on Twitter
Starting thread on Covid and hypertension:
Who's most likely to develop a blood clot post-COVID? New study offers answer
"Blood clots are an under-recognized potential complication of COVID-19"
Dr Gina Ferre MD on Twitter
Analysis thread on Twitter Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences