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The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
#blood clots#coagulopathy#fibrin#cytokines#Mpro#vascular#Endothelium
·biorxiv.org·
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.

“NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.

Turns out that Mpro, a viral protease [pro-tee-ace], can START the cascade.

a thread written for everyone:

Here's the takeaway: The Main protease (Mpro) of SARS-CoV-2—an enzyme that cuts up viral polyproteins—can also cleave a few host coagulation factors in a way that ACTIVATES them and BEGINS the blood clot cascade.”

#blood clots#vascular#Mpro#Discussion#bradykinin#thrombin#coagulopathy
·x.com·
NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Japan study: 65 million+ participants shows role of endothelial dysfunction in #longCOVID and leading to a potential chronic kidney disease and cardiovascular damage/disease.
#Endothelium#vascular#heart
·mdpi.com·
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
“In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.”
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
#vascular#blood clots#plasma alterations#long covid
·molmed.biomedcentral.com·
Alterations in plasma proteome during acute COVID-19 and recovery - Molecular Medicine
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
“With regard to COVID, terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to paint a portrait that lulls the reader into a false sense of security, drawing comparisons between a virus that has been around for less than five years to other viruses or conditions with respect to which the audience has grown familiar with. Moreover, even stock photos selected for certain news articles can subtly influence your response to the content expressed in that piece. A selected photo of a person gently cradling a tissue paper over their nose, instead of a person waiting for treatment in the ER, may give off the impression that they are harmlessly recovering from a tear-jerking soap opera instead of from a viral illness. In fact, we want to believe that COVID-19 is as gentle as a cold, as this outcome is far more pleasing, so this skewed presentation of the risk is far more palatable than what is expressed in the scientific literature.”
#vascular#organ damage#Endothelium#minimizing and outright propaganda
·whn.global·
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus

No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus

"The selection of words modulates the message...terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to...lull the reader into a false sense of security... COVID-19 is not primarily a respiratory infection. This virus can cause a systemic disease with far-reaching effects on the body, particularly blood vessels. Once SARS-CoV-2 enters the body, the virus can affect the ...blood vessels, causing inflammation and damage.

#inflammation#vascular#Endothelium
·x.com·
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Harriet Carroll: Recognise vax-induced long COVID on Twitter

Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots

#Long Covid#Clots#blood clots#microclots#vascular#Endothelium#vasculitis
·twitter.com·
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Retinal Abnormalities and COVID
Retinal Abnormalities and COVID
"Retinal microvascular abnormalities and impaired blood flow ap­pear to be emerging as signature ocular manifestations of COVID-19 infections, researchers have found..."
#retina#Eyes#vascular
·aao.org·
Retinal Abnormalities and COVID
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.

"The longer the period from COVID-19 infection the worse the vascular impairment...."

#vascular#Endothelium
·mdpi.com·
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
"Study shows that COVID-19, unlike other viruses, seems to impact the heart's small blood vessels...Chemical staining tests revealed blood clotting in the small blood vessels of the heart tissue. These fibrous blood clots may remain even after the virus is gone"
#Clots#blood clots#vascular#Heart
·newsnetwork.mayoclinic.org·
Blood clots in the heart are common in patients with COVID-19 - Mayo Clinic News Network
laurie allee on Twitter
laurie allee on Twitter
"study led by University at Buffalo confirmed...COVID-19 vaccines pose only trivial risk of venous thromboembolism (VTE), or blood clots. In addition, the study found that becoming infected with COVID-19 poses a significant risk of blood clots."
#Clots#blood clots#Deep Vein Thrombosis#vascular
·twitter.com·
laurie allee on Twitter