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The Cardiac pathophysiology of Covid-19
The Cardiac pathophysiology of Covid-19

“Findings emphasize that Covid-19’s myocardial pathology predominantly arises from fibrin thrombi within the coronary MICROVASCULAR network, especially in the abluminal spaces.

➡️This pathological process leads to myocardial fibre injury, necrosis, and ischemic changes( = fibrosis), contributing to both the acute symptoms and long-term sequelae (Long Covid).”

·x.com·
The Cardiac pathophysiology of Covid-19
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium

Covid, and even asymptomatic covid is an endothelial disease.

Polish study Study on endothelial cells shows SARS-CoV-2 disrupts cell elasticity, causing vascular damage even without full replication.

“Clinical data indicate that COVID-19 causes cardiovascular complications, regardless of the severity of the disease. In this work, we have shown that SARS-CoV-2 infection causes vascular dysfunction due to the modification of endothelial cell elasticity.”

·nature.com·
Remodeling of intracellular architecture during SARS-CoV-2 infection of human endothelium
COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type | Arteriosclerosis, Thrombosis, and Vascular Biology
COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type | Arteriosclerosis, Thrombosis, and Vascular Biology
“COVID-19 at all levels of severity was associated with significantly higher risk of MI, stroke, or all-cause mortality over 1003 days of follow-up."
·ahajournals.org·
COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type | Arteriosclerosis, Thrombosis, and Vascular Biology
Table 3 Adjusted hazard ratios (95% CI) comparing the incidence of arterial thrombotic events after versus before or without a COVID-19 diagnosis, in the pre-vaccination, vaccinated and unvaccinated cohorts, overall and according to COVID-19 severity
Table 3 Adjusted hazard ratios (95% CI) comparing the incidence of arterial thrombotic events after versus before or without a COVID-19 diagnosis, in the pre-vaccination, vaccinated and unvaccinated cohorts, overall and according to COVID-19 severity
“Adjusted hazard ratios (95% CI) comparing the incidence of arterial thrombotic events after versus before or without a COVID-19 diagnosis, in the pre-vaccination, vaccinated and unvaccinated cohorts, overall and according to COVID-19 severity”
Adjusted hazard ratios (95% CI) comparing the incidence of arterial thrombotic events after versus before or without a COVID-19 diagnosis, in the pre-vaccination, vaccinated and unvaccinated cohorts, overall and according to COVID-19 severity
·nature.com·
Table 3 Adjusted hazard ratios (95% CI) comparing the incidence of arterial thrombotic events after versus before or without a COVID-19 diagnosis, in the pre-vaccination, vaccinated and unvaccinated cohorts, overall and according to COVID-19 severity
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

Autopsy study in patients with COVID shows that: SARS-CoV-2 infects, replicates and persists in Macrophages within the coronary vasculature Since CARDIAC MACROPHAGES have a half-life of 8.8years they would act as VIRAL RESERVOIRS in Atherosclerotic plaques

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
·nature.com·
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Japan study: 65 million+ participants shows role of endothelial dysfunction in #longCOVID and leading to a potential chronic kidney disease and cardiovascular damage/disease.
·mdpi.com·
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
The big concern raised by this fresh study is that medium- to long-term harms on the body’s blood vessel network (the vascular system) may be much more common than that. And it could drive a new pandemic of cardiovascular disease over the coming years."
·iol.co.za·
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
·authorea.com·
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
New study offers clues as to how long COVID affects the heart | Houston Public Media
New study offers clues as to how long COVID affects the heart | Houston Public Media
“A study from Houston Methodist found some #LongCovid patients aren't getting enough blood to their heart.. The ability of endothelial cells, which play a key role in dilating arteries.. was diminished by 20% among 101 long covid patients who participated”
·houstonpublicmedia.org·
New study offers clues as to how long COVID affects the heart | Houston Public Media