SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease
Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease
COVID, heart disease and stroke
"COVID damages preferentially the inner linings of the blood vessels. That’s why you might hear COVID called a vascular disease — vascular means anything related to the blood vessels."
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.
"The longer the period from COVID-19 infection the worse the vascular impairment...."
Emmanuel on Twitter
ENDOTHELIAL dysfunction in COVID-19 infections may lead to CARDIOVASCULAR COMPLICATIONS. "Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients" https://ijbs.com/v19p1664.htm *ECFC (endothelial colony forming cells)
Jbm
SARS‐CoV‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks: effects specific to SARS-CoV-2, vascular dysfunction caused by an increase in inflammatory cytokines, dexamethasone prevents spike protein-induced ED.
BIRCH on Twitter
Even mild Covid can increase your chance of blood clots after the initial infection. *all images available as editable, printable files, DM for info.
Mike Hoerger, PhD MSCR MBA on Twitter
"I hope to god I'm wrong. I've never wanted to be more wrong in my life.... Worst case scenario... we are going to see a tsunami of cardiovascular disease over the next few decades." #LongCOVID
How COVID-19 Can Kill You
"COVID-19 can cause sudden death because the virus has a predilection to attack endothelial cells, which pave the blood vessel highways to all our organs...damaged endothelial cells can lead to blood clots, which can cause strokes and heart attacks."
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"Impaired endothelial function can be documented in convalescent COVID-19 patients, especially when residual clinical manifestations persist."
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
"Elevated D-dimer levels are a predictor of hypercoagulation complications in COVID-19. Patients with persistently elevated D-dimer levels after recovery from COVID-19 should be screened for thromboembolic complications, even if they are asymptomatic."
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
From 2020: "COVID-19 can be considered a vascular disease with regards to serious complications and causes of mortality...blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19."
Jeff The Leftist 🌹 on Twitter
Role of endothelial dysfunction in the severity of COVID‑19 infection (Review) (Oct 2022)
Website:
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
The big concern raised by this fresh study is that medium- to long-term harms on the body’s blood vessel network (the vascular system) may be much more common than that. And it could drive a new pandemic of cardiovascular disease over the coming years."
Deep vein thrombosis and pulmonary embolism in pediatric COVID-19
"Furthermore, the virus itself provokes a direct endothelial injury activating the coagulation cascade. The vascular endothelium is a key target-organ of SARS-Cov-2"
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
Eric Topol on Twitter
Analysis thread on Twitter: The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controls https://ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060785 @CircAHA by @jonathanasterne and colleagues
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
More evidence that LongCOVID symptoms are due to widespread endothelial damage and a failed fibrinolytic system. We again found numerous entrapped inflammatory molecules; and this time also antibodies in microclots
Neurovascular injury with complement activation and inflammation in COVID-19
A study that performed autopsies on the brains of COVID-19 patients who died shortly after infection found all patients had multifocal vascular damage in the brain which was accompanied by widespread endothelial cell activation
COVID-19 takes serious toll on heart health—a full year after recovery
Infected patients develop blood clots, heart inflammation, arrhythmias, and heart failure among others (
New study offers clues as to how long COVID affects the heart | Houston Public Media
“A study from Houston Methodist found some #LongCovid patients aren't getting enough blood to their heart.. The ability of endothelial cells, which play a key role in dilating arteries.. was diminished by 20% among 101 long covid patients who participated”
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
"Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury."