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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection
SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection

Using stem-cell-derived vascular cells, researchers found SARS-CoV-2 infects smooth muscle cells (SMCs), not endothelial cells.

Infected SMCs cause inflammation and clotting factors, explaining vascular issues seen in severe COVID-19 cases.

#vascular#Endothelium#blood clots#smooth muscle cells#inflammation
·biorxiv.org·
SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
“Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis”
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
#vascular#blood clots#Post-Acute Conditions#thrombotic endotheliitis#thromboinflammation#inflammation#Endothelium#von Willebrand Factor#platelet factor 4#serum amyloid A#α-2-antiplasmin#E-selectin#platelet endothelial cell adhesion molecule-1
·medrxiv.org·
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

Autopsy study in patients with COVID shows that: SARS-CoV-2 infects, replicates and persists in Macrophages within the coronary vasculature Since CARDIAC MACROPHAGES have a half-life of 8.8years they would act as VIRAL RESERVOIRS in Atherosclerotic plaques

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
#Heart#vascular#blood clots#Endothelium#Inflammation#atherosclerosis
·nature.com·
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Great analysis thread:

“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!

Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’

Simplified breakdown of the paper below!

#fibrin#blood clots#Endothelium#thromboinflammation#neuropathology#brain#brain injury#long covid#Neuroinflammation#inflammation#Viral Persistence#Immune system
·x.com·
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!