“A possible new diagnostic approach to Long COVID. Long COVID may involve microcirculatory blockages - tiny, persistent clots known as fibrinaloid microclots. These abnormal fibrin structures resist breakdown and can obstruct blood flow in the smallest vessels.🧵”
Thread by @ZdenekVrozina on Thread Reader App
SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins
“what and how SARS-CoV-2 factors make endothelial cells (ECs) sensitive to complement-mediated cytotoxicity.”
what and how SARS-CoV-2 factors make endothelial cells (ECs) sensitive to complement-mediated cytotoxicity.
Friesein (@Friesein) on X
“SARS-CoV-2 hijacks the clotting system of your body for its own purposes.
The spike protein binds to fibrin, rendering it toxic. Those toxic fibrin proteins damage blood vessel walls and drive an inflammatory response.
Other viruses don't do this.”
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
“Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis”
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Great analysis thread:
“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’
Simplified breakdown of the paper below!