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The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
“Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.”
Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains systemic inflammation and the hypercoagulant state, thus increasing thrombotic risk. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade.
#blood clots#coagulopathy#fibrin#cytokines#Mpro#vascular#Endothelium
·biorxiv.org·
The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
Japan study: 65 million+ participants shows role of endothelial dysfunction in #longCOVID and leading to a potential chronic kidney disease and cardiovascular damage/disease.
#Endothelium#vascular#heart
·mdpi.com·
The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
“With regard to COVID, terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to paint a portrait that lulls the reader into a false sense of security, drawing comparisons between a virus that has been around for less than five years to other viruses or conditions with respect to which the audience has grown familiar with. Moreover, even stock photos selected for certain news articles can subtly influence your response to the content expressed in that piece. A selected photo of a person gently cradling a tissue paper over their nose, instead of a person waiting for treatment in the ER, may give off the impression that they are harmlessly recovering from a tear-jerking soap opera instead of from a viral illness. In fact, we want to believe that COVID-19 is as gentle as a cold, as this outcome is far more pleasing, so this skewed presentation of the risk is far more palatable than what is expressed in the scientific literature.”
#vascular#organ damage#Endothelium#minimizing and outright propaganda
·whn.global·
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus - WHN
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus

No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus

"The selection of words modulates the message...terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to...lull the reader into a false sense of security... COVID-19 is not primarily a respiratory infection. This virus can cause a systemic disease with far-reaching effects on the body, particularly blood vessels. Once SARS-CoV-2 enters the body, the virus can affect the ...blood vessels, causing inflammation and damage.

#inflammation#vascular#Endothelium
·x.com·
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Harriet Carroll: Recognise vax-induced long COVID on Twitter

Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots

#Long Covid#Clots#blood clots#microclots#vascular#Endothelium#vasculitis
·twitter.com·
Harriet Carroll: Recognise vax-induced long COVID on Twitter
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.

"The longer the period from COVID-19 infection the worse the vascular impairment...."

#vascular#Endothelium
·mdpi.com·
Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study
Jbm
Jbm
SARS‐CoV‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks: effects specific to SARS-CoV-2, vascular dysfunction caused by an increase in inflammatory cytokines, dexamethasone prevents spike protein-induced ED.
#vascular#Clots#blood clots#Endothelium
·onlinelibrary.wiley.com·
Jbm
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
"Elevated D-dimer levels are a predictor of hypercoagulation complications in COVID-19. Patients with persistently elevated D-dimer levels after recovery from COVID-19 should be screened for thromboembolic complications, even if they are asymptomatic."
#D-dimer#blood clots#Clots#vascular#Endothelium#pulmonary embolism
·cureus.com·
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed

From 2020: "COVID-19 can be considered a vascular disease with regards to serious complications and causes of mortality...blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19."

#Clots#vascular#blood clots#Endothelium
·pubmed.ncbi.nlm.nih.gov·
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
The big concern raised by this fresh study is that medium- to long-term harms on the body’s blood vessel network (the vascular system) may be much more common than that. And it could drive a new pandemic of cardiovascular disease over the coming years."
#Heart#Stroke#Endothelium#vascular#Clots#blood clots#pulmonary embolism#Deep Vein Thrombosis
·iol.co.za·
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
#Long Covid#female#estrogen#Clots#blood clots#Heart#vascular#Endothelium
·authorea.com·
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
More evidence that LongCOVID symptoms are due to widespread endothelial damage and a failed fibrinolytic system. We again found numerous entrapped inflammatory molecules; and this time also antibodies in microclots
#Clots#microclots#vascular#Endothelium#blood clots
·cardiab.biomedcentral.com·
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
New study offers clues as to how long COVID affects the heart | Houston Public Media
New study offers clues as to how long COVID affects the heart | Houston Public Media
“A study from Houston Methodist found some #LongCovid patients aren't getting enough blood to their heart.. The ability of endothelial cells, which play a key role in dilating arteries.. was diminished by 20% among 101 long covid patients who participated”
#Endothelium#vascular#Heart#Long Covid
·houstonpublicmedia.org·
New study offers clues as to how long COVID affects the heart | Houston Public Media
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
"Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury."
#Endothelium#lung#vascular#Clots#blood clots
·frontiersin.org·
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress