Dr Gina Ferre MD on Twitter
Analysis thread on Twitter Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences
Jbm
SARS‐CoV‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks: effects specific to SARS-CoV-2, vascular dysfunction caused by an increase in inflammatory cytokines, dexamethasone prevents spike protein-induced ED.
BIRCH on Twitter
Even mild Covid can increase your chance of blood clots after the initial infection. *all images available as editable, printable files, DM for info.
Mike Hoerger, PhD MSCR MBA on Twitter
"I hope to god I'm wrong. I've never wanted to be more wrong in my life.... Worst case scenario... we are going to see a tsunami of cardiovascular disease over the next few decades." #LongCOVID
How COVID-19 Can Kill You
"COVID-19 can cause sudden death because the virus has a predilection to attack endothelial cells, which pave the blood vessel highways to all our organs...damaged endothelial cells can lead to blood clots, which can cause strokes and heart attacks."
07853890
"Impaired endothelial function can be documented in convalescent COVID-19 patients, especially when residual clinical manifestations persist."
The signs that Covid-19 has caused a blood clot - seek immediate help
"Study published last month in the journal Circulation...Covid patients were 21 times more likely to have a heart attack or stroke during their first week of a Covid diagnosis. After 4 weeks, patients were 4 times more likely to suffer either of these."
A Case of Deep Vein Thrombosis After Recovery From COVID-19 and Its Association With Elevated D-dimers
"Elevated D-dimer levels are a predictor of hypercoagulation complications in COVID-19. Patients with persistently elevated D-dimer levels after recovery from COVID-19 should be screened for thromboembolic complications, even if they are asymptomatic."
Even a mild case of COVID can put you at higher risk for blood clots and death, according to a new study
"...individuals who had been diagnosed with COVID but weren’t hospitalized were still at a risk nearly 3 times as high for venous thromboembolism—blood clots & pulmonary embolism—when compared with similar individuals who hadn’t had COVID."
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State
COVID-19 Demonstrates That Inflammation Is a Hyperviscous State "complications of COVID-19 are caused by blood hyperviscosity driven by marked hyperfibrinogenemia. This results in a distinctive hyperviscosity syndrome...A change in blood viscosity causes a threefold inverse change in blood flow..."
New research finds microclotting and inflammatory molecule abnormalities in long-COVID
New research finds microclotting and inflammatory molecule abnormalities in long-COVID
COVID-19 as a Vascular Disease: Lesson Learned from Imaging and Blood Biomarkers - PubMed
From 2020: "COVID-19 can be considered a vascular disease with regards to serious complications and causes of mortality...blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19."
These Symptoms Can Point to Cardiovascular Complications From COVID-19
How COVID-19 Can Lead to Amputation—And Other Potential Cardiovascular System Complications to Know
Even mild Covid raises the chance of heart attack and stroke. What to know about the risks ahead
The big concern raised by this fresh study is that medium- to long-term harms on the body’s blood vessel network (the vascular system) may be much more common than that. And it could drive a new pandemic of cardiovascular disease over the coming years."
Risk for First-Time Clot Events Raised After COVID-19 Diagnosis - Physician's Weekly
Risk for First-Time Clot Events Raised After COVID-19 Diagnosis
Deep vein thrombosis and pulmonary embolism in pediatric COVID-19
"Furthermore, the virus itself provokes a direct endothelial injury activating the coagulation cascade. The vascular endothelium is a key target-organ of SARS-Cov-2"
Hormone Therapy in the Era of the COVID-19 Pandemic: A Review
"...the benefits of menopausal hormone therapy outweigh the risks even in the situation of COVID-19 pandemic and vaccination. Caution is needed in relation to the risk of thrombosis"
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
Eric Topol on Twitter
Analysis thread on Twitter: The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controls https://ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060785 @CircAHA by @jonathanasterne and colleagues
Circulationaha
“Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales”
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
More evidence that LongCOVID symptoms are due to widespread endothelial damage and a failed fibrinolytic system. We again found numerous entrapped inflammatory molecules; and this time also antibodies in microclots
Blood clot risk remains elevated nearly a year after COVID-19
"Blood clot risk remains elevated nearly a year after COVID-19"
laurie allee on Twitter
Starting thread on Covid related aneurysms
Ruptured cerebral aneurysms in COVID-19 patients: A review of literature with case examples - PubMed
"...strongly implicated to cause degenerative vascular changes that may predispose patients to cerebral aneurysm formation, change in size or morphology, and resultant aneurysm rupture."
Rth2
Biomarker derived risk scores predict venous thromboembolism and major bleeding among patients with COVID-19
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Can COVID-19 increase the risk of developing deep vein thrombosis?
"One study analyzed the sequelae of more than one million people affected in Sweden and noted that the risk of suffering from DVT increases by five times."
Management of venous thromboembolism in COVID-19 - The Pharmaceutical Journal
Related: "Management of venous thromboembolism in COVID-19"
A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection
"A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection..."
What Is a DVT?
"COVID-19 increases people's risk of dangerous blood clots and bleeding for months after infection, researchers say.
The new findings suggest that COVID-19 is an independent risk factor for deep vein thrombosis, pulmonary embolism and bleeding."