COVID-19 and the Brain
From 2020: "Vascular events such as strokes have been reported in COVID-19 patients. It is thought that SARS-CoV-2 causes a thickening of the blood, which leads to blood clots"
Dr Claire Taylor on Twitter
1/A reminder that #LongCovid patients have microclots. We are sending children to school with no mitigations and a 5% chance of a disease that damages you blood vessels.🩸 ALL 80 patients tested in this paper had moderate microclots. Green is microclots.
Resia Pretorius on Twitter
Excited to share our webinar: “COVID-induced Coagulopathy (CAC): The clot thickens…or not?" presented by Dr Mark Walsh, myself and @dbkell , and moderated by @doctorasadkhan It is available at
What Does COVID Do to Your Blood?
The Impact of Covid-19 Blood Clots Throughout the Body:
New study offers clues as to how long COVID affects the heart | Houston Public Media
“A study from Houston Methodist found some #LongCovid patients aren't getting enough blood to their heart.. The ability of endothelial cells, which play a key role in dilating arteries.. was diminished by 20% among 101 long covid patients who participated”
Long covid clot risk
“COVID-19 triggers a massive release of biomolecules from the immune system…these molecules can gum up the blood and make it more likely to form clots…a new study is showing that people with long COVID have a higher risk of blood clots.”
Blood-clotting imbalance persists in Long COVID, research finds
"higher levels of blood-clotting booster called von Willebrand Factor, lower levels of protein that normally breaks down VWF...blood vessels still being damaged long after the initial infection, & specific cells of the immune system were at abnormal levels
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
“The result, as is strongly manifested in platelet-poor plasma (PPP) of individuals with Long COVID, is extensive fibrin amyloid microclots that can persist, can entrap other proteins, and that may lead to the production of various autoantibodies.”
Resia Pretorius on Twitter
Typical inflammatory conditions like cardiovascular disease, diabetes etc are known to have hypercoagulation - which is a hallmark of systemic inflammation. Microclots and platelet hyperactivation are both present in these conditions. Longcovid has significantly more microclots
James on Twitter
Patient Anecdote thread on Twitter: Today I travelled 4000miles to get tested for Microclots to test the theory that this is causing my #longcovid symptoms. Turns out I have them. This testing needs to be made accessible to all those suffering around the world so they can be treated (1)
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
"Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury."
WesElyMD on Twitter
Detailed analysis thread on Twitter: 1/🧵 Micro Clots & Endothelial Dysfunction in Long COVID
Plus new Epidemiology in @JAMA_current some say proves #LongCOVID is a hoax⁉️
Truth is…endothelial dysfunction plus inflammation can lead to life-altering brain & body dz.
Let’s explore data
Long COVID: Coagulopathies and Microclots - RTHM
Long COVID: Coagulopathies and Microclots
Tiny, Menacing Microclots May Explain Long COVID’s Symptoms
“One core question is: Do these microclots actually represent a root cause, or are they in response to something else that's ongoing?” says Michael VanElzakker PhD, co-founder of PolyBio Research Foundation, which is focused on studying viral reservoir:
Tiny, Menacing Microclots May Explain Long COVID’s Symptoms
Hannah Davis on Twitter
Anecdote: Big news: I was lucky to get tested for micro blood clots, & I have a lot of them! #LongCovid
Healthy control blood on the left. Mine on the right. The green is all microclots!
These clots are likely blocking oxygen from getting around my body & could explain many symptoms. 1/
New research finds microclotting and inflammatory molecule abnormalities in long-COVID
New research finds microclotting and inflammatory molecule abnormalities in long-COVID
Relative hypercoagulopathy of the SARS-CoV-2 Beta and Delta variants when compared to the less severe Omicron variants is related to TEG parameters, the extent of fibrin amyloid microclots, and the severity of clinical illness.
Relative hypercoagulopathy of the SARS-CoV-2 Beta and Delta variants when compared to the less severe Omicron variants is related to TEG parameters, the extent of fibrin amyloid microclots, and the severity of clinical illness.
The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Related The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Circresaha
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
First evidence of inflammatory micro clots in blood of individuals suffering from Long COVID
"New research indicates that an overload of various inflammatory molecules, literally "trapped" inside insoluble microscopic blood clots (micro clots), might be the cause of some of the lingering symptoms experienced by individuals with Long COVID."
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications - PubMed
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
Diagnose microclots in LongCovid patients | Kernls
Develop an accessible, lab-based method to diagnose microclots in LongCovid patients Millions suffering from LongCovid don't have access to a regular test for diagnosis. Top researchers develop a widely available method to help explain the condition's debilitating symptoms.
charlos on Twitter
This is starting to get frustrating ~ Another #LongCovid pt travels across the world to Germany & gets a simple blood test which reveals a clear biomarker - #MicroClots
The fact we still don’t have this simple test readily available is a failure. What are we waiting for??
First evidence of inflammatory micro clots in blood of individuals suffering from Long COVID
"New research indicates that an overload of various inflammatory molecules, literally "trapped" inside insoluble microscopic blood clots (micro clots), might be the cause of some of the lingering symptoms experienced by individuals with Long COVID."