When SARS-CoV-2 persists in the bone marrow, it’s not just hiding. New cells are literally born carrying viral material - mainly megakaryocytes - platelets. Strongest evidence - megakaryocytes and monocytes. Weaker branches - dendritic cells, erythroid precursors, EPCs (hypothesis). HIV has done the same thing for decades. But nobody wanted to hear it.
“🔬Viruses don’t just cause short-term illness.
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵”
“At 58min 30 seconds into this podcast interview, I describe CoV-AIDS and list the immune cells depleted and/or directly infected by SARS-COV-2. Viral Persistence: A National Treatment and Research Agenda for Long Covid / Long Covid Action Project — Last Born In The Wilderness”
Yesterday we released “The Persistent Dozen.”
It includes 12 papers on SARS-CoV-2 persistence. There are 100s & we are currently sorting through them, but here are 12 interesting ones.
There is no doubt, SC2 & spike protein persist.
“…one team found that almost two years after infection, long COVID patients had not yet cleared the virus from their gut tissue. These persistent viral reservoirs appear to leak spike protein — the part of the virus that gives coronaviruses their distinctive ‘crown’ appearance — into blood circulation, potentially driving inflammation of the brain and other organs, and increasing health consequences such as heart disease.
While early efforts are underway to help clear persistent viral reservoirs, more well-designed clinical trials are desperately needed to help the millions suffering from long COVID return to normal life.”
“Basically this is not a standard respiratory virus but one that finds its way into every cell that has a receptor which exists on our blood vessels to a protein called AcE2 - so the virus through the spike protein can enter many tissues in our body- colon, pancreas, lung, blood vessels of brain etc.
Of concern is that the virus seems capable of replicating and persisting years after the infection. The consequence is chronic inflammation and other issues we will discuss.”
“COVID-19 Virus Can Stay in the Body More Than a Year after Infection New research provides the strongest evidence yet of long-term viral persistence in otherwise healthy people.”
Autopsies of 15 COVID-19 cases showed SARS-CoV-2 in multiple organs (lungs, heart, liver, etc.) even in non-immunocompromised individuals.
The virus mutated differently in each organ, supporting theories of viral reservoirs and rapid evolution.
“The SARS-CoV-2 spike protein stays in the brain after a COVID-19 infection.”
“Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance
Altogether, our results suggest that in some individuals, a standard 5-day course of nirmatrelvir-ritonavir starting around the time of symptom onset may not completely eliminate the virus. Thus, after treatment ends, the virus can rebound if an effective adaptive immune response has not fully developed. These findings on the role of target cell preservation and incomplete viral clearance also offer a possible explanation for viral rebounds following other antiviral treatments for SARS-CoV-2.”
