Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Covid and Viral Persistence
COVID-19 Virus Can Persist in the Body More Than a Year after Infection - PolyBio Research Foundation
Plasma-based antigen persistence in the post-acute phase of COVID-19
Early Biological Markers of Post-Acute Sequelae of SARS-CoV-2 Infection
These patients were given a monoclonal antibody to tag viral RNA, then sent through a PET scanner for imaging to show the persistence. Even patients that didn't have long cov*d had viral RNA. #viral persistence
Use of total-body PET imaging to identify deep-tissue SARS-CoV-2 viral reservoirs and T cell responses in patients with Long COVID - PolyBio Research Foundation
USE OF TOTAL-BODY PET IMAGING TO IDENTIFY DEEP-TISSUE SARS-COV-2 VIRAL RESERVOIRS AND T CELL RESPONSES IN PATIENTS WITH LONG COVID
laurie allee on Twitter
AMAZING STUDY : MULTIPLE OMICRON SUB-VARIANTS in MULTIPLE TISSUE locations,
such as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections
Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
MULTIPLE OMICRON SUB-VARIANTS in MULTIPLE TISSUE locations,
such as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections
Model of long COVID based on the persistence of virus
"A pathophysiological model of long COVID based on the persistence of the SARS-CoV-2 virus"
Every Breaking Wave on Twitter
Another recent paper on viral persistence
SARS-CoV-2 can remain for 100's of days (one instance 505 days @ detection), including autopsy, stool analysis, and other empirical bases
Viral persistence, reactivation, and mechanisms of long COVID
Viral persistence, reactivation, and mechanisms of long COVID
Fulltext
Association of SARS-CoV-2 infection and persistence with long COVID
Fulltext
"The presented evidence suggests that the duration of SARS-CoV-2 infection in patients can persist considerably longer than suggested"
Long COVID: The Persistence of SARS-CoV-2 in the Mucous Membranes May Be A Factor - Inserm Newsroom
"Long COVID: The Persistence of SARS-CoV-2 in the Mucous Membranes May Be A Factor"
Chris Turnbull on Twitter
Detailed thread on Twitter New study shows that those infected by Sars2/Covid have pockets of compartmentalized virus in organs across the body, including the heart and testis containing new variants implying virus is able to spawn new variants from ongoing infection ala HIV—180 unique variants found.
laurie allee on Twitter
Comprehensive, regularly updated thread on SarsCov2 viral persistence:
Why viral reservoirs are a prime suspect for long covid sleuths
"Why viral reservoirs are a prime suspect for long COVID sleuths"
A possible explanation for long covid gains traction
"viral reservoirs where the coronavirus can stick around in the body long after a person is initially infected."
Jonathan Mesiano-Crookston 🌬️🔅#COV1DisAirborne on Twitter
Detailed Twitter thread
Levels of COVID in the saliva correlated with symptoms, including taste loss.
Upon recovery, this asymptomatic cohort exhibited sustained salivary IgG antibodies against SARS-CoV-2. Suggesting virus in saliva for a while.
SARS-CoV-2 infection of the oral cavity and saliva
Study of SARS2 in saliva
Scientists hope viruses hiding out in patients hold answers to long COVID
"Research released in December shows the virus can persist throughout the body and brain for months. That suggests it may be able to hide out in human cells and tissues, not unlike the way HIV and the shingles-causing chickenpox virus do."
B. Carfree on Twitter
The CDC recommends condom use for weeks (?) after one is infected with SARS-2.
We know many people have persistent infections in GI, testes, brains, and more, so it wouldn't be any big surprise if LC can spread it sexually or if it restarted replicating in respiratory tissue.
SARS-CoV-2 infection of the oral cavity and saliva
The concept that #longCOVID could be infectious is potentially possible, given that we know there is viral persistence in saliva for a lot longer than most are aware. At least 2 months according to this paper.
Dr. Gustavo Aguirre-Chang on Twitter
We reaffirm that the main cause of LongCOVID is the Viral Persistence It should not be considered Post-Infectious,Sequelae There is an active infection that mainly affects the blood vessels and there are often co-infections Something similar happens in CFS
355949081 chronic covid long covid or post acute covid syndrome pacs is an infectious disease that mainly affect the blood vessels
CHRONIC COVID (LONG COVID OR POST ACUTE COVID SYNDROME: PACS) IS AN INFECTIOUS DISEASE THAT MAINLY AFFECT THE BLOOD VESSELS
Chris Turnbull on Twitter
Detailed Twitter thread: New study solidifies the fact that Covid reverse trabscibes into human DNA similar to HIV causing persistent infection:
Long COVID: Viral infection may persist in gut for up to 7 months
"...research sheds light on long COVID as it reveals viral infection may persist in the gut for up to 7 months."
Asymptomatic SARS-COV-2 infection in children's tonsils
"Positive immunostaining in adenotonsillar tissue samples suggest lymphoid tissue can be a reservoir of SARS-CoV-2 and may play an important role in community dissemination...unclear for how long the tissue can sustain SARS-CoV-2 in a persistent infection"
Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome - PubMed
"In this report, we propose a model for the pathophysiology of the long COVID presentation based on increased proinflammatory cytokine production that results from the persistence of the SARS-CoV-2 virus or one of its molecular components."
SARS-CoV-2 infection and persistence throughout the human body and brain
"Our data prove that SARS-CoV-2 causes systemic infection and can persist in the body for months."
Coronavirus can persist for months after traversing entire body
The coronavirus that causes Covid-19 can spread within days from the airways to the heart, brain and almost every organ system in the body, where it may persist for months, a study found."