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Thread by @LongCFoundation on Thread Reader App
Thread by @LongCFoundation on Thread Reader App

Yesterday we released “The Persistent Dozen.”

It includes 12 papers on SARS-CoV-2 persistence. There are 100s & we are currently sorting through them, but here are 12 interesting ones.

There is no doubt, SC2 & spike protein persist.

LongCOVID

Yesterday we released “The Persistent Dozen.” It includes 12 papers on SARS-CoV-2 persistence. There are 100s & we are currently sorting through them, but here are 12 interesting ones. There is no doubt, SC2 & spike protein persist. #LongCOVID
#Viral Persistence#Long Covid#Post-Acute Conditions#analysis#compilations#resources#Long Covid Foundation
·threadreaderapp.com·
Thread by @LongCFoundation on Thread Reader App
Opinion: Long COVID is solvable, but we need more clinical trials
Opinion: Long COVID is solvable, but we need more clinical trials

“…one team found that almost two years after infection, long COVID patients had not yet cleared the virus from their gut tissue. These persistent viral reservoirs appear to leak spike protein — the part of the virus that gives coronaviruses their distinctive ‘crown’ appearance — into blood circulation, potentially driving inflammation of the brain and other organs, and increasing health consequences such as heart disease.

While early efforts are underway to help clear persistent viral reservoirs, more well-designed clinical trials are desperately needed to help the millions suffering from long COVID return to normal life.”

one team found that almost two years after infection, long COVID patients had not yet cleared the virus from their gut tissue. These persistent viral reservoirs appear to leak spike protein — the part of the virus that gives coronaviruses their distinctive “crown” appearance — into blood circulation, potentially driving inflammation of the brain and other organs, and increasing health consequences such as heart disease.While early efforts are underway to help clear persistent viral reservoirs, more well-designed clinical trials are desperately needed to help the millions suffering from long COVID return to normal life.
#Advocacy#Covid Statistics#Long Covid#Post-Acute Conditions#Viral Persistence#Long Covid blood markers#research
·latimes.com·
Opinion: Long COVID is solvable, but we need more clinical trials
Long COVID appears to be driven by ‘long infection’. Here’s what the science says
Long COVID appears to be driven by ‘long infection’. Here’s what the science says
“…in a perspective article published in the latest Medical Journal of Australia, we argue that much, if not all, long COVID appears to be driven by the virus itself persisting in the body.”
in a perspective article published in the latest Medical Journal of Australia, we argue that much, if not all, long COVID appears to be driven by the virus itself persisting in the body.
#Long Covid#Post-Acute Conditions#Viral Persistence
·theconversation.com·
Long COVID appears to be driven by ‘long infection’. Here’s what the science says
Fantastic review on chronic SARS-CoV-2 infections by virological superstars Richard Neher & Alex Sigal in Nature Microbiology. I’ll do a short overview, outline a couple minor quibbles, & defend the honor of ORF9b w/some stats & 3 striking sequences from the past week.
Fantastic review on chronic SARS-CoV-2 infections by virological superstars Richard Neher & Alex Sigal in Nature Microbiology. I’ll do a short overview, outline a couple minor quibbles, & defend the honor of ORF9b w/some stats & 3 striking sequences from the past week.
“Fantastic review on chronic SARS-CoV-2 infections by virological superstars Richard Neher & Alex Sigal in Nature Microbiology. I’ll do a short overview, outline a couple minor quibbles, & defend the honor of ORF9b w/some stats & 3 striking sequences from the past week.”
#Long Covid#Post-Acute Conditions#Viral Persistence#Discussion#analysis
·x.com·
Fantastic review on chronic SARS-CoV-2 infections by virological superstars Richard Neher & Alex Sigal in Nature Microbiology. I’ll do a short overview, outline a couple minor quibbles, & defend the honor of ORF9b w/some stats & 3 striking sequences from the past week.
If there is a viral reservoir of SARS-CoV-2 why did the Stanford Paxlovid trial fail? The drug might be insufficient, or poor penetration in some reservoirs, or inappropriate end points, etc. Dominique Salmon MD PhD
If there is a viral reservoir of SARS-CoV-2 why did the Stanford Paxlovid trial fail? The drug might be insufficient, or poor penetration in some reservoirs, or inappropriate end points, etc. Dominique Salmon MD PhD
“If there is a viral reservoir of SARS-CoV-2 why did the Stanford Paxlovid trial fail? The drug might be insufficient, or poor penetration in some reservoirs, or inappropriate end points, etc. Dominique Salmon MD PhD”
#Viral Persistence#antiviral#Long Covid#Post-Acute Conditions#Paxlovid#treatment#Dominique Salmon MD PhD#Video
·x.com·
If there is a viral reservoir of SARS-CoV-2 why did the Stanford Paxlovid trial fail? The drug might be insufficient, or poor penetration in some reservoirs, or inappropriate end points, etc. Dominique Salmon MD PhD
Towards a cure for long COVID: the strengthening case for persistently replicating SARS‐CoV‐2 as a driver of post‐acute sequelae of COVID‐19
Towards a cure for long COVID: the strengthening case for persistently replicating SARS‐CoV‐2 as a driver of post‐acute sequelae of COVID‐19
“the strengthening case for persistently replicating SARS-CoV-2 as a driver of post-acute sequelae of COVID-19”
the strengthening case for persistently replicating SARS-CoV-2 as a driver of post-acute sequelae of COVID-19
#Long Covid#Post-Acute Conditions#Viral Persistence
·onlinelibrary.wiley.com·
Towards a cure for long COVID: the strengthening case for persistently replicating SARS‐CoV‐2 as a driver of post‐acute sequelae of COVID‐19
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes | PNAS
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes | PNAS

SARS-CoV-2 peptide fragments can reassemble with dsRNA into proinflammatory complexes, amplifying immune responses.

These complexes trigger cytokine secretion in various cell types, mimicking severe COVID-19 inflammation.

#Viral Persistence#Inflammation#cytokines#immune dysregulation#Immune system#peptide fragments#Post-Acute Conditions#Long Covid
·pnas.org·
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes | PNAS
Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study
Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study
“The findings of this multicohort study indicate that SARS-CoV-2 antigens can be detected in the blood of a substantial proportion of individuals up to 14 months after infection. While approximately one in five asymptomatic individuals was antigen-positive, roughly half of all individuals reporting ongoing cardiopulmonary, musculoskeletal, and neurologic symptoms were antigen-positive.”
The findings of this multicohort study indicate that SARS-CoV-2 antigens can be detected in the blood of a substantial proportion of individuals up to 14 months after infection. While approximately one in five asymptomatic individuals was antigen-positive, roughly half of all individuals reporting ongoing cardiopulmonary, musculoskeletal, and neurologic symptoms were antigen-positive.
#Viral Persistence#Long Covid#Post-Acute Conditions
·clinicalmicrobiologyandinfection.com·
Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study