The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBio
“We and others have found that antihistamine drugs, particularly histamine receptor H1 (HRH1) antagonists, potently inhibit SARS-CoV-2 infection. In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein.”
We and others have found that antihistamine drugs, particularly histamine receptor H1 (HRH1) antagonists, potently inhibit SARS-CoV-2 infection. In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein.
Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients
"this analysis suggests that primary care diagnosis and treatment with antihistamines, plus azithromycin in selected cases, may treat COVID-19 and prevent progression to severe disease in elderly patients."
Identification of antiviral antihistamines for COVID-19 repurposing
"Efforts to identify approved drugs with in vitro activity against SARS-CoV-2 resulted in identification of antiviral sigma-1 receptor ligands, including antihistamines in the histamine-1 receptor binding class... diphenhydramine, hydroxyzine & azelastine"
Starting thread on Benadryl /other antihistamines & potential use in Covid / Long Covid:
"Further long COVID research will be needed to truly put antihistamines to the test, but 2 promising case reports from California could help kickstart the process."
