Disrupting the residual triggers of COVID-19 in patients with long COVID
“Spatial transcriptomics reveals activation of SARS-CoV-2-related signaling pathways in the epipharynx of patients with long COVID”
Thread by @1goodtern on Thread Reader App
“So I did what the journalist should have done. I went looking for some data. We all know that doctors and nurses and everyone else in healthcare are sicker now than five years ago, right? I mean, you do, don't you? That across all the massive workforce of the NHS, sickness absence rates are now 25% higher than the pre-pandemic average? Right?”
So I did what the journalist should have done.
I went looking for some data.
We all know that doctors and nurses and everyone else in healthcare are *sicker now than five years ago*, right?
I mean, you do, don't you?
That across all the massive workforce of the NHS, sickness absence rates are now 25% higher than the pre-pandemic average?
Right?
JCI - Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes
UCSF study of 35 people with Long COVID had fewer mature NK cells 4 months after infection.
Lower NK cell levels linked to more symptoms like fatigue and brain fog.
NK cells clear infected cells, which may explain lasting symptoms.
HIV/AIDS and Long COVID are Very Similar
“HIV/AIDS & COVID-19, particularly long COVID, share several significant similarities, especially in terms of viral persistence, T cell damage, immune system dysfunction, & activation of other pathogens. These parallels are important for understanding the long-term effects of both infections and their impact on the immune system.”
With a healthy immune system, one can usually reach ketosis in a matter of hours of fasting, an important part of cycling through energy that helps to regenerate immune cells. In Long Covid, this is not possible due to persistent gluconeogenesis, thus ongoing immune dysfunction.
“With a healthy immune system, one can usually reach ketosis in a matter of hours of fasting, an important part of cycling through energy that helps to regenerate immune cells. In Long Covid, this is not possible due to persistent gluconeogenesis, thus ongoing immune dysfunction.”
LARGEST MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY (GWAS) of Long COVID
“This implies that some people may be genetically predisposed to developing post-viral syndromes after COVID-19.
Overall, these findings provide important insights into the genetic basis of Long COVID.
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome
"Upon physical activity, affected patients exhibit reduced systemic oxygen extraction & oxidative phosphorylation capacity.. these are mediated by dysfunctions in mitochondria & microcirculation.. maintained by.. immune activation."