Scientists Discover Drug That Could Finally End Long COVID Suffering
WEHI scientists discovered a drug that blocks long COVID in mice and may improve acute treatment options beyond current antivirals like Paxlovid.
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
Update on my protocol. I spent approx. 2 weeks with a special ChatGPT prompt to create my individual Long Covid & ME/CFS treatment plan. It’s a massive plan with a 4 week introduction phase. After that first real benefits should be visible after 3 months and long lasting benefits…— Marco 🇩🇪🇪🇺🇺🇦 (@Gmwetz) February 26, 2025
“Update on my protocol. I spent approx. 2 weeks with a special ChatGPT prompt to create my individual Long Covid & ME/CFS treatment plan. It’s a massive plan with a 4 week introduction phase. After that first real benefits should be visible after 3 months and long lasting benefits after around 12 months. Maybe it’s risky - but I am declining slowly anyway. So, I will give it a try. My last attempt - if this is not successful, so be it.
But as I said, I see already changes (10 days in) My Lunalae is coming back on my thumbs, my wound healing is faster, less cold hands and my skin / scalp is less itchy and better heart rate while standing.
But there are also things what I would call “side effects” like pain and additional exhaustion. But I will hang in there.
I don’t know what it will bring. But why should I wait ? For what ? When ? We are loosing our lives NOW.
I will update you regularly.”
Effects of an 8‐week high‐dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post‐COVID syndrome: A randomized controlled trial
A positive early course Long Covid trial: Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial
Metformin reduces the risk of Long COVID or Death over 6 months in an Emulated Target Trial of Primarily Omicron-infected Adults without Diabetes or Prediabetes New-User, Active-Comparator Analysis
Study in the US during the Omicron wave followed 248 metformin users over 6 months.
Starting metformin within a week of COVID reduced the risk of Long COVID or death by 53%.
Safe and inexpensive with results aligning with earlier data.
I'm the acupuncturist/herbalist who told everyone to take Berberine, Taurine, Lumbrokinase, and Minerals for Long Covid. The protocol is strictly palliative, meant to improve QoL. The work I've done since then on Lingering Pathogenic illness and TCM is meant to be curative, a WIP
LongCovidPharmD on Substack
summary of a Harvard preprint of a long covid patient survey addressing patient responses to a variety of possible Long Covid treatments
Feels like a good time for a thread about all things exercise for people living with infection (and exposure)-associated complex chronic illnesses (IACCs) such as , and chronic /tick- and vector-borne illness. Let’s start with a trip down memory lane. 🧵 1/
“Feels like a good time for a thread about all things exercise for people living with infection (and exposure)-associated complex chronic illnesses (IACCs) such as #MECFS, #LongCOVID and chronic #Lyme /tick- and vector-borne illness. Let’s start with a trip down memory lane. 🧵 1/“
I got COVID in March of 2020, followed by 2.5 years of Long COVID. Combination antivirals seemingly cured me.
Evusheld tx my long COVID
“Evusheld tx my long COVID
Evusheld is a combo of 2 long-acting monoclonal antibodies Tixagevimab/cilgavimab
in 2021 I got this tx for acute COVID infection ⬇️ Prevented me from becoming hospitalized, I felt better within 45 mins of injection & my long COVID from 2020 resolved” Thread:
Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial
“Participants were randomly assigned via 2 × 3 parallel factorial randomisation (1:1:1:1:1:1) to receive metformin plus ivermectin, metformin plus fluvoxamine, metformin plus placebo, ivermectin plus placebo, fluvoxamine plus placebo, or placebo plus placebo.
When metformin was started within 3 days of symptom onset, the HR was 0·37 (95% CI 0·15–0·95). There was no effect on cumulative incidence of long COVID with ivermectin (HR 0·99, 95% CI 0·59–1·64) or fluvoxamine (1·36, 0·78–2·34) compared with placebo.
There was no effect on cumulative incidence of long COVID with ivermectin (HR 0·99, 95% CI 0·59–1·64) or fluvoxamine (1·36, 0·78–2·34) compared with placebo.
…Outpatient treatment with metformin reduced long COVID incidence by about 41%, with an absolute reduction of 4·1%, compared with placebo. Metformin has clinical benefits when used as outpatient treatment for COVID-19 and is globally available, low-cost, and safe.”
A clinical trial of repurposed HIV antivirals in LongCOVID - PolyBio Research Foundation
“A clinical trial to test if two repurposed HIV antivirals (Truvada and Maraviroc) can reduce symptom burden in patients with LongCOVID.”
Long Covid nearly broke me. Now I’m curing fellow sufferers
“Dr Ben Sinclair...became so ill after contracting coronavirus he could barely move or talk. Now he has opened pioneering clinics fighting a disease that afflicts more than two million people in the UK”
Breakthrough in Long COVID: An investigator-initiated trial (IIT) with Hyundai Bioscience's Xafty by UCSD
(So of course we will probably never get access to this.)
“The goal of this study is to confirm that niclosamide can solve the complex symptoms of Long COVID through multiple mechanisms such as virus suppression, inflammation suppression, and neuroprotection. We hope that the clinical trial will be successful and provide a practical treatment option for Long COVID patients, which will be historic."
The goal of this study is to confirm that niclosamide can solve the complex symptoms of Long COVID through multiple mechanisms such as virus suppression, inflammation suppression, and neuroprotection. We hope that the clinical trial will be successful and provide a practical treatment option for Long COVID patients, which will be historic."