Quick summary for non-academics:
“Antibodies from HIV patients can block the spike protein, indicating a similar structure between the two viruses.”
Brain inflammation may be the reason behind muscle fatigue after infection and injury
“Infectious or chronic diseases such as long COVID, Alzheimer’s disease and traumatic brain injury can cause inflammation in the brain, or neuroinflammation, that weakens muscles. “
Infectious or chronic diseases such as long COVID, Alzheimer’s disease and traumatic brain injury can cause inflammation in the brain, or neuroinflammation, that weakens muscles.
Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection
“PASC patients showed differences in brain activation in fatigue-related and additional regions. • PASC patients also had increased frontal task-related activation compared to controls. • Findings suggest PASC patients may exert more mental effort during demanding tasks.”
PASC patients showed differences in brain activation in fatigue-related and additional regions.•PASC patients also had increased frontal task-related activation compared to controls.•Findings suggest P
Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID | Brain Communications | Oxford Academic
“Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID.
While vaccination decreases the severity of acute COVID infection, the sobering conclusion of our study is that vaccination prior to infection did not alter the subsequent neurologic manifestations of long COVID in our clinic population."
Anyone else have musical auditory hallucinations w ? Also having more trouble identifying objects (as in I see a shape of something and briefly think it is something else). Coming up on year 5 & the brain damage seems pretty progressive.
“Anyone else have musical auditory hallucinations w #LongCovid? Also having more trouble identifying objects (as in I see a shape of something and briefly think it is something else). Coming up on year 5 & the brain damage seems pretty progressive.”
Between 2% and 14% of COVID survivors develop a syndrome called postural orthostatic tachycardia syndrome (POTS) (1).
“Between 2% and 14% of COVID survivors develop a syndrome called postural orthostatic tachycardia syndrome (POTS) (1).
However, it is commonly attributed to stress and anxiety.
This is the surprising story of how POTS (and possibly Long COVID) might be linked to an even rarer syndrome...🧵”
Actor Tilda Swinton was unable to get out of bed for three weeks due to a SARS-CoV-2 infection.
“I was coughing like an old gentleman who smoked a pipe for 70 years, and had nasty vertigo,” Tilda said. “... the worst thing is how it affected my brain.”
Excess weight increases the risk for neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis
“Excess weight increases the risk for neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis”
Excess weight increases the risk for neurological and neuropsychiatric symptoms in post-COVID-19 condition: A systematic review and meta-analysis
Penn Study Finds Serotonin Reduction Causes Long COVID Symptoms
Long COVID patients show reduced serotonin levels due to decreased tryptophan absorption, leading to symptoms like brain fog and memory loss.
Long COVID and recovery from Long COVID: quality of life impairments and subjective cognitive decline at a median of 2 years after initial infection - BMC Infectious Diseases
“Long COVID and recovery from Long COVID: quality of life impairments and subjective cognitive decline at a median of 2 years after initial infection”
Long COVID and recovery from Long COVID: quality of life impairments and subjective cognitive decline at a median of 2 years after initial infection
‘We need Psychologists… but please don’t psychologise Long Covid’ | BPS
Great article. David Joffe quote, "please do not psychologise ME/CFS or Long Covid...this is a direct organic, neurological condition, with a plethora of complex outcomes, including severe consequences for autonomy and quality of life."
A doctor friend of mine said that every covid long hauler that he has seen has abnormal connective tissue samples when seen under the microscope. Long Covid will be known as a connective tissue disease which disrupts the Neuroimmune, Autonomic and Brain-Micro-Vessel Axis.
“A doctor friend of mine said that every covid long hauler that he has seen has abnormal connective tissue samples when seen under the microscope. Long Covid will be known as a connective tissue disease which disrupts the Neuroimmune, Autonomic and Brain-Micro-Vessel Axis.”
Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study
“In this population of healthy young adult US Marines with mostly either asymptomatic or mild acute COVID-19, one fourth reported physical, cognitive, or psychiatric long-term sequelae of infection. The Marines affected with PASC showed evidence of long-term decrease in functional performance suggesting that SARS-CoV-2 infection may negatively affect health for a significant proportion of young adults.”
n this population of healthy young adult US Marines with mostly either asymptomatic or mild acute COVID-19, one fourth reported physical, cognitive, or psychiatric long-term sequelae of infection. The Marines affected with PASC showed evidence of long-term decrease in functional performance suggesting that SARS-CoV-2 infection may negatively affect health for a significant proportion of young adults.
Did I not get the memo?
“Why do emergency department reports and hospital discharge summaries not mention that my patient tested positive for SARS-CoV-2 (or had “a really bad cold” or “the worst flu ever”) 1 month before they presented to hospital with weakness, falls, confusion, dyspnea, heart failure, acute kidney injury, or non–ST-elevation myocardial infarction? Doesn’t that seem relevant? It does to me.”pos
Persistent dysfunctions of brain metabolic connectivity in long-covid with cognitive symptoms
FDG-PET scans revealed persistent brain dysfunction in long covid
“Hypoconnectivity and absence of hypometabolism suggest that connectivity derangement in frontal networks could be related to protraction of neurological symptoms in long-term COVID patients.”