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Emerging viral threats combated by a potent new dual lipid kinase inhibitor
Emerging viral threats combated by a potent new dual lipid kinase inhibitor
“The researchers demonstrated selective dual inhibition of the lipid kinases PIP4K2C and PIKfyve by RMC-113 and target engagement by its related clickable analog. Advanced lipidomics revealed alteration of SARS-CoV-2-induced phosphoinositide signature by RMC-113 and linked its antiviral effect with functional PIP4K2C and PIKfyve inhibition. The researchers also discovered PIP4K2C's roles in SARS-CoV-2 entry, RNA replication, and assembly/egress, validating…”
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Emerging viral threats combated by a potent new dual lipid kinase inhibitor