Psilocybin desynchronizes the human brain - Nature
Claude summary: This research provides new insights into how psilocybin affects large-scale brain activity and connectivity. The key finding is that psilocybin causes widespread desynchronization of brain activity, particularly in association cortex areas. This desynchronization correlates with the intensity of subjective psychedelic experiences and may underlie both the acute effects and potential therapeutic benefits of psilocybin. The desynchronization of brain networks may allow for increased flexibility and plasticity, potentially explaining both the acute psychedelic experience and longer-term therapeutic effects.
Psilocybin acutely caused profound and widespread brain FC changes (Fig. 1a) across most of the cerebral cortex (P < 0.05 based on two-sided linear mixed-effects (LME) model and permutation testing), but most prominent in association networks
Across psilocybin sessions and participants, FC change tracked with the intensity of the subjective experience (Fig. 1f and Extended Data Fig. 4).