Insulin Secretagogue - an overview | ScienceDirect Topics
Case Study on Lennox-Gastaut Syndrome | Epilepsy Foundation
What is Lennox-Gastaut syndrome? The Lennox-Gastaut syndrome (LGS) is a type of epilepsy with multiple different types of seizures, particularly tonic (stiffening) and atonic (drop) seizures. Intellectual development is usually delayed and often worsens over time.
Nerve growth factor enhances antigen and other secretagogue-induced histamine release from rat peritoneal mast cells in the absence of phosphatidylserine - Journal of Allergy and Clinical Immunology
(PDF) Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains
Secretagogue - Wikipedia
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Insulin Secretagogues | Hormone Health Network
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(PDF) Changes in the Dimeric State of Neuronal Nitric Oxide Synthase Affect the Kinetics of Secretagogue-Induced Insulin Response
Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway
Aspirin has been widely recommended for acute and chronic conditions for over 2,000 years. Either single or repetitive doses are commonly used for analgesic and antipyretic reasons and to prevent heart attacks, stroke, and blood clot formation. Recent ...
Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis | Request PDF
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Inhibitors of the Cytochrome P-450 Enzymes Block the Secretagogue-Induced Release of Corticotropin in Mouse Pituitary Tumor Cells on JSTOR
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Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting β-cells | Biochemical Journal | Portland Press
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Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors
Glucagon-like peptide-1 (GLP-1) participates in glucose homeostasis and feeding behavior. Because GLP-1 is rapidly inactivated by the enzymatic cleavage of dipeptidyl peptidase-4 (DPP4) long-acting GLP-1 analogues, for example, exenatide and DPP4 inhibitors, for example, liraglutide, have been developed as therapeutics for type 2 diabetes mellitus (T2DM). However, the inefficient clinical performance and the incidence of side effects reported on the existing therapeutics for T2DM have led to the development of a novel therapeutic strategy to stimulate endogenous GLP-1 secretion from enteroendocrine L cells. Since the GLP-1 secretion of enteroendocrine L cells depends on the luminal nutrient constituents, the intestinal nutrient sensors involved in GLP-1 secretion have been investigated. In particular, nutrient sensors for tastants, cannabinoids, and bile acids are able to recognize the nonnutritional chemical compounds, which are abundant in medicinal plants. These GLP-1 secretagogues derived from medicinal plants are easy to find in our surroundings, and their effectiveness has been demonstrated through traditional remedies. The finding of GLP-1 secretagogues is directly linked to understanding of the role of intestinal nutrient sensors and their recognizable nutrients. Concurrently, this study demonstrates the possibility of developing novel therapeutics for metabolic disorders such as T2DM and obesity using nutrients that are readily accessible in our surroundings.
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This system is used in conjunction with the 25 tesla split-helix magnet in cell 6.
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Simulated Cholinergic Reinnervation of β (INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing β Cell and Cholinergic Cell
Cholinergic neurons can functionally support pancreatic islets in controlling blood sugar levels. However, in islet transplantation, the level of cholinergic reinnervation is significantly lower compared to orthotopic pancreatic islets. This abnormal reinnervation affects the survival and function of islet grafts. In this study, the cholinergic reinnervation of beta cells was simulated by 2D and 3D coculture of INS-1 and NG108-15 cells. In 2D culture conditions, 20 mM glucose induced a 1.24-fold increase () in insulin secretion from the coculture group, while in the 3D culture condition, a 1.78-fold increase () in insulin secretion from heterotypic pseudoislet group was observed. Glucose-stimulated insulin secretion (GSIS) from 2D INS-1 cells showed minimal changes when compared to 3D structures. E-cadherin expressed in INS-1 and NG108-15 cells was the key adhesion molecule for the formation of heterotypic pseudoislets. NG108-15 cells hardly affected the proliferation of INS-1 cells in vitro. Heterotypic pseudoislet transplantation recipient mice reverted to normoglycemic levels faster and had a greater blood glucose clearance compared to INS-1 pseudoislet recipient mice. In conclusion, cholinergic cells can promote insulin-secreting cells to function better in vitro and in vivo and E-cadherin plays an important role in the formation of heterotypic pseudoislets.
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Diabetic Emergencies: Hypoglycemia Caused by Insulin Secretagogues, Part 1
Stavros Liatis, Nikolaos Katsilambros Sulfonylureas and non-sulfonylurea insulin secretagogues (meglitinides) exert
Two types of chloride channel on duct cells cultured from human fetal pancreas | American Journal of Physiology-Cell Physiology
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