Fluid Resuscitation of the Adult Trauma Patient: Where Have We Been and Where Are We Going? - PubMed
The resuscitation of an adult trauma patient has been researched and written about for the past century. Throughout those discussions, 2 major controversies persist when discussing resuscitation methods: (1) the ideal choice of fluid type to use during the initial resuscitation period, and (2) the i …
Hostage to History: The Duration of Antimicrobial Treatment for Acute Streptococcal Pharyngitis - PubMed
Oral antimicrobial treatment of acute streptococcal pharyngitis commonly is given for 10 days. An investigation was conducted of journal publications and textbooks from the dawn of the antimicrobial era to the present in order to discover the basis for this settled practice. Current treatment durati …
[Venom as a cure--some notes on ancient medicine] - PubMed
Very little is known today about the linguistics and facts relating to venoms in the ancient world. The article concerns itself initially with the terminology: How were venoms conceptualized and what position did they occupy among medicines and other poisons? Additionally ancient knowledge of the co …
Thirty years of phase I radiochemotherapy trials: Latest development - PubMed
Radiochemotherapy is undergoing a complete expansion. Currently, possibilities of treatment combination are skyrocketting, with different anticancer and targeted molecules, different radiotherapy techniques, and dose escalation with each therapy. The development of a modern phase I radiochemotherapy …
Controlled Drug Delivery: Historical perspective for the next generation - PubMed
The modern day drug delivery technology is only 60years old. During this period numerous drug delivery systems have been developed. The first generation (1950-1980) has been very productive in developing many oral and transdermal controlled release formulations for clinical applications. On the othe …
The History of Target-Controlled Infusion - PubMed
Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technica …
[How to dose correctly? An overview of debates in the United States, Great Britain and Germany (1830s to 1970s)] - PubMed
The dispute over low and high potencies is no longer current in today's homeopathy, but from the 1830s to the 1960s it played a major role in scientific discourse. The devotees of high potencies claimed to be the only true Hahnemannians, while their antagonists tried to practise a scientific, modern …
[A history of antipsychotic long-acting injections in the treatment of schizophrenia] - PubMed
From a historical perspective, this article describes the use of antipsychotic long-acting injections (LAI) in the treatment of schizophrenia, a disorder that was defined in the final years of the 19th century. An efficient treatment for schizophrenia was discovered only in 1952 with the introductio …
INSIGHTS INTO AVICENNA'S KNOWLEDGE OF GASTROINTESTINAL MEDICINE AND HIS ACCOUNT OF AN ENEMA DEVICE - PubMed
Avicenna (980-1037 AD), also known as Sheikh or-Raeis, was an Muslim philosopher, physician, surgeon, astronomer, politician, encyclopedist, and mathematician. Avicenna's writings comprise of five books, know as the Al-Qanun fi al-Tibb (The Canon of Medicine) and the canon covers a wide variety of m …
The development of dose-dense adjuvant chemotherapy - PubMed
Dose-dense chemotherapy has made a significant contribution to the adjuvant treatment of breast cancer. One way of achieving dose-density is through the use of sequential therapy with noncross resistant therapies to cause cell kill in tumors composed of heterogeneous cells. Another way to achieve th …
15 years of ATTEMPTS: a macromolecular drug delivery system based on the CPP-mediated intracellular drug delivery and antibody targeting - PubMed
Traditionally, any drug intended for combating the tumor would distribute profoundly to other organs and tissues as lack of targeting specificity, thus resulting in limited therapeutic effects toward the tumor but severe drug-induced toxic side effects. To prevail over this obstacle of drug-induced …
23. From stealthy, controlled release polymersomes to cylinder-shaped 'filomicelles' for imaging and delivery: Original research article: Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles, 2004 - PubMed
23. From stealthy, controlled release polymersomes to cylinder-shaped 'filomicelles' for imaging and delivery: Original research article: Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles, 2004
21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: oral approaches: Original research article: a novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 2004 - PubMed
21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: oral approaches: Original research article: a novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 2004
20. Multi-targeting system with fusion between thermoresponsive carriers and mild hyperthermia: Original research article: Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate) (1999) - PubMed
20. Multi-targeting system with fusion between thermoresponsive carriers and mild hyperthermia: Original research article: Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate) (1999)
19. Targeted nanoparticles for smarter cancer therapy: Original research article: Folate receptor targeted biodegradable polymeric doxorubicin micelles, 2004 - PubMed
19. Targeted nanoparticles for smarter cancer therapy: Original research article: Folate receptor targeted biodegradable polymeric doxorubicin micelles, 2004
18. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs: reflections and commentary a decade later: Original research article: Biodegradable block copolymers for delivery and proteins water-insoluble drugs, 2001 - PubMed
18. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs: reflections and commentary a decade later: Original research article: Biodegradable block copolymers for delivery and proteins water-insoluble drugs, 2001
17. Histidine based pH-responsive polymeric micelle for tumor: Original research article: Polymeric micelle for tumor pH folate-mediated targeting, 2003 - PubMed
17. Histidine based pH-responsive polymeric micelle for tumor: Original research article: Polymeric micelle for tumor pH folate-mediated targeting, 2003
15. Vitamin E TPGS based nanoparticles of biodegradable polymers for controlled release of anticancer drugs: Original research article: a novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS (2003) - PubMed
15. Vitamin E TPGS based nanoparticles of biodegradable polymers for controlled release of anticancer drugs: Original research article: a novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS (2003)
13. From tissue engineering to therapeutic cancer vaccines: Original research article: Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery, 2000 - PubMed
13. From tissue engineering to therapeutic cancer vaccines: Original research article: Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery, 2000
12. Biodegradable polymer nanoparticles as protein delivery systems: Original research articles: Design of biodegradable particles for protein delivery (2002), Chitosan nanoparticles as delivery systems for doxorubicin (2001); design of microencapsulated chitosan microspheres for colonic drug delivery (1998) - PubMed
12. Biodegradable polymer nanoparticles as protein delivery systems: Original research articles: Design of biodegradable particles for protein delivery (2002), Chitosan nanoparticles as delivery systems for doxorubicin (2001); design of microencapsulated chitosan microspheres for colonic drug delivery (1998)
11. Biodegradable electrospun fibers as drug delivery system for local cancer treatment: a rugged path to the bright future: Original research article: Biodegradable electrospun fibers for drug delivery, 2003 - PubMed
11. Biodegradable electrospun fibers as drug delivery system for local cancer treatment: a rugged path to the bright future: Original research article: Biodegradable electrospun fibers for drug delivery, 2003
10. Biophysics of cell membrane and nanoparticle interface: Original research article: Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake, 2002 - PubMed
10. Biophysics of cell membrane and nanoparticle interface: Original research article: Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake, 2002
9. Diagnostic and therapeutic applications of biocompatible gold nanorods: Original research article: PEG-modified gold nanorods with a stealth character for in vivo applications, 2006 - PubMed
9. Diagnostic and therapeutic applications of biocompatible gold nanorods: Original research article: PEG-modified gold nanorods with a stealth character for in vivo applications, 2006