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We are looking for an enthusiastic and motivated synthetic organic chemist or medicinal chemist to join our research team. The fellow will join an interdisciplinary team developing HIV-1 integrase strand transferinhibitors (INSTIs) intended to retain antiviral efficacy against resistant mutant forms of integrase. The position is primarily synthetic organic in nature with a focus on designing and synthesizing heterocyclicmolecules. The fellow will combine insights derived from antiviral assays together with structures of synthetic inhibitors bound to integrase to guide the ongoing design of next-generation analogs. Relevant publications include: ACS. Chem. Biol. 2016, 11, 1074; J. Med. Chem. 2017 60, 7315; Science 2020, 367, 810.

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The PDQ® Editorial Boards use formal criteria to assess the strength of the evidence from published research studies on cancer interventions.

Levels of Evidence for Integrative, Alternative, and Complementary Therapies is about how to weigh the strength of the evidence obtained in cited research studies. Get detailed information this formal ranking system in this summary for clinicians.

Levels of Evidence for Integrative, Alternative, and Complementary Therapies is about how to weigh the strength of the evidence obtained in cited research studies. Get detailed information this formal ranking system in this summary for clinicians.

Levels of Evidence for Integrative, Alternative, and Complementary Therapies is about how to weigh the strength of the evidence obtained in cited research studies. Get detailed information this formal ranking system in this summary for clinicians.

Levels of Evidence for Integrative, Alternative, and Complementary Therapies is about how to weigh the strength of the evidence obtained in cited research studies. Get detailed information this formal ranking system in this summary for clinicians.

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The PDQ® Editorial Boards use formal criteria to assess the strength of the evidence from published research studies on cancer interventions.

Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as pre …

Users' guides to the medical literature: XIX. Applying clinical trial results. A. How to use an article measuring the effect of an intervention on surrogate end points. Evidence-Based Medicine Working Group

Numerous methodologic questions await definitive research and answers, but in the meantime teams developing authoritative systematic reviews can take certain steps to ensure that their approaches to grading the quality of articles meet applicable scientific standards. Clinicians, program administrat …

Physicians must decide when the evidence is sufficient to adopt a new clinical policy. Analysis of large clinical and administrative databases is becoming an important source of evidence for changing clinical policies. Because such analysis cannot control for the effects of all potential confounding …