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Pigmentary Glaucoma and Pigment Dispersion Syndrome - EyeWiki
Pigmentary Glaucoma and Pigment Dispersion Syndrome - EyeWiki
Pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) represent a spectrum of the same disease characterized by excessive pigment liberation throughout the anterior segment of the eye. The classic triad consists of dense trabecular meshwork pigmentation, mid-peripheral iris transillumination defects, and pigment deposition on the posterior surface of the central cornea. Pigment accumulation in the trabecular meshwork reduces aqueous outflow facility and may result in elevation of intraocular pressure (IOP), as seen in pigment dispersion syndrome, or in optic nerve damage associated with visual field loss, as seen in pigmentary glaucoma. Pigmentary glaucoma and PDS occur when pigment is released from the iris pigment epithelium due to rubbing of the posterior iris against the anterior lens zonules. The disease is more prevalent in males, and typically presents in the 3rd-4th decade of life.
significantly flatter corneas
more affected eye was noted to have more iris-lens contact than the less affected eye
greater iris concavity, more posterior iris insertion) were also more common in patients with PDS or PG.
collapse of trabecular sheets, free pigment granules and cellular debris clogging the intertrabecular spaces, and macrophages and degenerated trabecular endothelial cells filled with pigment.
Diagnosis
Visual symptoms are unusual except in patients with visual field loss.
intermittent IOP elevation
brought about by exercise or dark exposure
roughly 1/3 of patients demonstrated extensive anterior chamber pigment
pigment reversal sign,” where the trabecular meshwork is found to be darker in the superior quadrant when compared with the inferior quadrant.
·eyewiki.org·
Pigmentary Glaucoma and Pigment Dispersion Syndrome - EyeWiki
Overactive Bladder Syndrome: Evaluation and Management
Overactive Bladder Syndrome: Evaluation and Management
Overactive bladder (OAB) syndrome is a chronic medical condition which has a major influence on the quality of life in a significant amount of the population. OAB affects performance of daily activities and has an estimated prevalence of 16.5%. Many sufferers ...
agents
agents with reduced blood-brain barrier penetrance (such as trospium and darifenacin) may prevent the co-vagolytic influence on the cardiovascular system that may lead to alternations in heart rate and blood pressure
·ncbi.nlm.nih.gov·
Overactive Bladder Syndrome: Evaluation and Management
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
creatinine clearance ranging from 30 to 80 mL/min
moderate and severe hepatic impairment.
increase in heart rate that correlates with increasing plasma concentrations.
500 mg metformin immediate release tablets twice daily reduced the steady-state systemic exposure of trospium by approximately 29% for mean
have an eye problem called "uncontrolled narrow-angle glaucoma"
·dailymed.nlm.nih.gov·
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
·dailymed.nlm.nih.gov·
These highlights do not include all the information needed to use Trospium Chloride Tablets safely and effectively. See full prescribing information for Trospium Chloride Tablets. Trospium Chloride Tablets, for oral use Initial U.S. Approval: 2004
New once‐daily formulation for trospium in overactive bladder
New once‐daily formulation for trospium in overactive bladder
Aims: We examined the relative efficacy and safety of trospium 20 mg bid and 60 mg extended release formulations and position this drug against other antimuscarinic agents. Methods: Data were ident...
·onlinelibrary.wiley.com·
New once‐daily formulation for trospium in overactive bladder
Anticholinergic Medications
Anticholinergic Medications
Clinical characteristics of anticholinergic toxicity include anhidrosis, anhidrotic hyperthermia, vasodilation-induced flushing, mydriasis, urinary retention, and neurological symptoms, including delirium, agitation, and hallucinations. The memory aid “red as a beet, dry as a bone, blind as a bat, mad as a hatter, hot as a hare, full as a flask’ often serves as means of remembering the common symptoms of anticholinergic toxicity
prostate hypertrophy
Clinical characteristics of anticholinergic toxicity include anhidrosis, anhidrotic hyperthermia, vasodilation-induced flushing, mydriasis, urinary retention, and neurological symptoms, including delirium, agitation, and hallucinations. The memory aid “red as a beet, dry as a bone, blind as a bat, mad as a hatter, hot as a hare, full as a flask’ often serves as means of remembering the common symptoms of anticholinergic toxicity
·ncbi.nlm.nih.gov·
Anticholinergic Medications
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
proven ocular side effects from oral ingestion of these anticholinergics, the prescribing physician should be notified by the managing eye care provider.. patients with decreased hepatic and/or renal function may be at higher risk of overdose or of experiencing side effects than patients with normal hepatic and/or renal function.7 Interestingly, co-administration of medications that can inhibit the P-450 enzymes in the liver responsible for metabolizing a variety of substances and medications can lead to a build-up of toxic by-products of anticholinergic OBS medications.7 Specifically, medications like buproprion, fluoxetine, paroxetine, terbinafine, quinidine, cimetidine, ritonavir, ketoconazole, itraconazole, verapamil, cyclosporine, erythro- mycin, clarithromycin, and fluconazole, and even grapefruit juice, can lead to a faster build- up of toxic levels of OBS anticholinergics.7
·ovpjournal.org·
Ocular Side Effects of Oxybutynin and Other Oral Anticholinergics Used In the Management of Overactive Bladder Syndrome: A Review ~borgman2.pdf
Intermountain Healthcare - Intermountain | Omada
Intermountain Healthcare - Intermountain | Omada
Omada is a 16-week online program that fits seamlessly into your life, so you can lose weight and lower your risk of disease without taking time away from the things you love.
·go.omadahealth.com·
Intermountain Healthcare - Intermountain | Omada
Uses of Castor Oil for Cats – A Full Guide - Cat Attitudes
Uses of Castor Oil for Cats – A Full Guide - Cat Attitudes
Groom your cat to perfection with our castor oil, a natural grooming product that will leave your kitty's coat looking healthy and soft! Learn the benefits and risks of castor oil for your cat.
·catattitudes.com·
Uses of Castor Oil for Cats – A Full Guide - Cat Attitudes
DMSO: Safety, Handling, & Recipes - Organicbiomama
DMSO: Safety, Handling, & Recipes - Organicbiomama
DMSO is an abbreviation for Dimethyl Sulfoxide and it is a 100% natural substance. When applied to the skin DMSO penetrates deep into tissues and will carry
·organicbiomama.com·
DMSO: Safety, Handling, & Recipes - Organicbiomama
The Health Benefits of DMSO: What You Need to Know
The Health Benefits of DMSO: What You Need to Know
Discover the therapeutic potential of DMSO for various conditions from wound healing to stroke treatment. Learn how this versatile compound can benefit your health.
·earthclinic.com·
The Health Benefits of DMSO: What You Need to Know
Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review
Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review
Neurodegeneration is the term describing the death of neurons both in the central nervous system and periphery. When affecting the central nervous system, it is responsible for diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s ...
·ncbi.nlm.nih.gov·
Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review
Beginning Exercise: Best Way To Start Working Out
Beginning Exercise: Best Way To Start Working Out
To get on the path to fitness, figure out an exercise routine that works best for your lifestyle, gradually increase your activity level and go at a steady pace.
·health.clevelandclinic.org·
Beginning Exercise: Best Way To Start Working Out
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease in the United States, affecting up to 30% of adults. There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and nonalcoholic steatohepatitis (NASH), defined as 5% or greater hepatic steatosis plus hepatocellular injury and inflammation, with or without fibrosis. Individuals with obesity are at highest risk of NAFLD. Other established risk factors include metabolic syndrome and type 2 diabetes mellitus. Although NAFLD is common and typically asymptomatic, screening is not currently recommended, even in high-risk patients. NAFLD should be suspected in patients with elevated liver enzymes or hepatic steatosis on abdominal imaging that are found incidentally. Once other causes, such as excessive alcohol use and hepatotoxic medications, are excluded in these patients, risk scores or elastography tests can be used to identify those who are likely to have fibrosis that will progress to cirrhosis. Liver biopsy should be considered for patients at increased risk of fibrosis and when other liver disorders cannot be excluded with noninvasive tests. Weight loss through diet and exercise is the primary treatment for NAFLD. Other treatments, such as bariatric surgery, vitamin E supplements, and pharmacologic therapy with thiazolidinediones or glucagon-like peptide-1 analogues, have shown potential benefit; however, data are limited, and these therapies are not considered routine treatments. NAFL typically follows an indolent course, whereas patients with NASH are at higher risk of death from cardiovascular disease, cancer, and end-stage liver disease. (Am Fam Physician. 2020;102(10):603–612. Copyright © 2020 American Academy of Family Physicians.)
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease in the United States, affecting up to 30% of adults
. There are two forms of NAFLD: nonalcoholic fatty liver (NAFL), defined as 5% or greater hepatic steatosis without hepatocellular injury or fibrosis, and
Most patients with NAFL will have a benign, nonprogressive disease course. Only 20% develop NASH, and 20% of those with NASH develop cirrhosis.
·aafp.org·
Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management
Cinnamon ~NIH
Cinnamon ~NIH
This fact sheet provides basic information about cinnamon—common names, usefulness and safety, and resources for more information.
·nccih.nih.gov·
Cinnamon ~NIH
Flaxseed and Flaxseed Oil ~NIH
Flaxseed and Flaxseed Oil ~NIH
This fact sheet provides basic information about flaxseed and flaxseed oil—common names, usefulness and safety, and resources for more information.
flaxseed may help with blood sugar levels in some people with type 2 diabetes.
Don’t eat raw or unripe flaxseeds, which may contain potentially toxic compounds.
Flaxseed may be unsafe during pregnancy
could worsen constipation or, in rare cases, cause an intestinal blockage
For More InformationUsing Dietary Supplements WiselyKnow the Science: How Medications and Supplements Can InteractKnow the Science: How To Make Sense of a Scientific Journal Article
·nccih.nih.gov·
Flaxseed and Flaxseed Oil ~NIH
***** Turmeric ~NCCIH, NIH
***** Turmeric ~NCCIH, NIH
This fact sheet provides basic information about turmeric—common names, usefulness and safety, and resources for more information. Javanese turmeric (Curcuma xanthorrhiz) is a different plant and not discussed in this fact sheet.
Turmeric may be unsafe for use during pregnancy in amounts greater than those commonly found in food. Little is known about whether it’s safe to use turmeric in amounts greater than those commonly found in food while breastfeeding.
·nccih.nih.gov·
***** Turmeric ~NCCIH, NIH
Telehealth Education | Veterans Affairs
Telehealth Education | Veterans Affairs
The Health and Healing classes and programs offered by VA Salt Lake City Health Care System brings your VA care closer to you in your home through VA Video Connect (VVC), VA’s secure video platform. VVC enables Veterans and their caregivers to connect with their VA providers from a location of their choosing and do not require a co-pay when the Veteran is at home or another non-VA location. To find a class offered in person or virtually, or a program that supports your own goals and care plan, review the list below!
·va.gov·
Telehealth Education | Veterans Affairs