7. Roots to Sky: Clinical Research & Treatment

The brain’s waste disposal system has hidden pathways. A new study reveals a previously unknown route, changing our map of how the brain stays clean and offering new clues for understanding neurological disease.

Researchers discovered that altering the body’s natural rhythm can help protect the brain from Alzheimer’s damage. By turning off a circadian protein in mice, they raised NAD+ levels and reduced harmful tau buildup. The findings suggest that adjusting the body’s clock may one day help prevent neurodegeneration.

A new study suggests nitrous oxide may offer a new treatment option for older adults with treatment-resistant depression.

A multinational analysis and Swedish registry data show higher dementia mortality after age 80 and a twofold dementia risk in those with type 1 diabetes.

Acupuncture significantly restores ovarian endocrine and vascular function in polycystic ovary syndrome (PCOS) through neuromodulation of the hypothalamic-pituitary-ovarian (HPO) axis.

Acupuncture and herbal medicine found effective for lung cancer treatment in integrative medicine settings.

Researchers have finally seen and measured the tiny alpha-synuclein oligomers that may ignite Parkinson’s disease. With the ultra-sensitive ASA-PD imaging method, they captured these clusters in brain tissue, finding larger and more numerous versions in patients with Parkinson’s. The discovery could mark a turning point in diagnosing and treating the disease, revealing the first visible signs long before symptoms appear.

Gain insights into polycystic ovary syndrome through the lens of Traditional Chinese Medicine on Me & Qi. Delve into the causes and explore natural TCM remedies for effective relief and wellness.

Teclistamab therapy shows potential in achieving drug-free remission in patients with refractory autoimmune diseases, with manageable cytokine release syndrome.

When the buzz on colon cleanses ramps up on social media, so do inquiries from patients. Here’s what physicians need to know.

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A long-term Australian study found that calcium supplements do not raise dementia risk in older women, countering previous fears. The research followed more than 1,400 participants for nearly 15 years and revealed no harmful cognitive effects. Scientists say these results should reassure those using calcium to prevent osteoporosis, though more research is needed across broader populations.

Treatment with the investigational psychedelic GH001 was linked with significant improvements in TRD that persist for at least 6 months, a new phase 2b trial shows.

For many IBS patients, gluten may not be the real culprit behind their symptoms. A new study found a gluten-free sham caused symptom flare-ups at nearly the same rate as challenges with actual wheat and gluten.

One in six laboratory-confirmed bacterial infections are resistant to antibiotic treatments, the World Health Organization said on Monday, calling for the medicines to be...

A large-scale analysis of U.S. mass shootings finds little support for claims that antidepressants cause violent behavior, suggesting most perpetrators were not taking psychiatric medication at the time of their attacks.

Scientists have pinpointed Y1 receptor neurons in the brain that can override chronic pain signals when survival instincts like hunger or fear take precedence. Acting like a neural switchboard, these cells balance pain with other biological needs. The research could pave the way for personalized treatments that target pain at its brain source—offering hope for millions living with long-term pain.

In a randomized clinical trial, transcutaneous auricular vagus nerve stimulation improves symptoms in patients with erythematotelangiectatic rosacea.

Common medications like doxycycline, minocycline, and hydrochlorothiazide are associated with an increased risk for clinically significant skin hyperpigmentation, a study shows.

Both sugar-sweetened and diet drinks raise the risk for metabolic dysfunction-associated steatotic liver disease, with artificial sweeteners linked to an even greater risk.

Some evidence supports certain diets, but large, high-quality studies are lacking.

Five years on, long COVID’s clinical picture is sharpening, revealing persistent lung changes, immune dysregulation, and a complex but vital role for rehabilitation.

Learn about the latest research on acupuncture from MSK and how our investigators are studying the benefits of acupuncture for relieving the side effects of cancer and its therapies.

Acupuncture delivered three times weekly produced substantially larger reductions in Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS) scores than sham acupuncture in adults with refractory IBS, with benefits sustained through eight weeks and no serious adverse events.

New research from Houston Methodist reveals how obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate the buildup of amyloid-β plaques in the brain. These vesicles even cross the blood–brain barrier, making them powerful but dangerous connectors between body fat and brain health.

New research demonstrates that long COVID can be a severely disabling condition. A recent study found individuals with lasting symptoms report worse daily function than 98% of the general population, with a significant negative impact on their overall quality of life.

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This guideline on premature ovarian insufficiency (POI) offers best practice advice on the care of women with POI.