Mood & Mind

Overactivation of dopamine neurons may directly drive their death, explaining why movement-controlling brain cells degenerate in Parkinson’s. Mice with chronically stimulated neurons showed the same selective damage seen in patients, along with molecular stress responses. Targeting this overactivity could help slow disease progression.

Drug combination targeting lax airways is nearing an FDA submission

Alzheimer’s disease is traditionally seen as a brain disorder, but new research using fruit flies reveals that it also affects organs and tissues throughout the body.

New findings suggest that dysfunction in the brain’s glymphatic system—a key waste clearance pathway—may contribute to cognitive impairments in adults with ADHD, shedding light on a lesser-known biological mechanism behind the disorder.

People with depression who were more optimistic at the start of treatment—and whose optimism increased during treatment—were more likely to benefit from SSRIs, according to a recent study, raising the possibility of tailoring treatments based on psychological traits.

A University of Exeter study finds a new treatment for depression could be a "significant advance".

A new treatment for depression, Stanford neuromodulation therapy, works eight times faster than the currently approved protocol and causes remission in nearly 80 percent of patients, according to recent research.

Depression is a very complex disorder and we simply have no good evidence that antidepressants help sufferers to improve

Scientists found that sleep plays an active role in transforming how memories are stored. After an immersive experience, participants remembered the order of events better after sleeping, suggesting the brain prioritizes storylines over details during deep sleep.

New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.

New data challenge old beliefs — get the latest on alcohol’s role in cancer, cognitive decline, and mental health. Learn how to update AUDIT use, patient talks, and prescribing practices.

Join a discussion with the experts for an enlightening journey into the intricate world of managing patients with bipolar depression. Credit available for th...

A surprising discovery in spider brains has led scientists to uncover a hidden waste removal system in the human brain. Its breakdown may explain the progressive neuron loss seen in Alzheimer’s disease, offering a new target for early intervention.

Microplastics are everywhere- from the water bottles we use to our clothes. While they are a serious health concern for all humans, research has found that it particularly impacts those with dementia.

Despite claims that antidepressants may be just delivering a placebo effect, three-quarters of people who tried them in a large study said they helped

Brain imaging, known as functional MRI, combined with machine learning can predict a treatment response based on one's depression "biotype."

Higher urinary metal levels were associated with poorer cognition and increased risk for dementia in a new study.

A recent study shows that better pre-treatment response inhibition in individuals with trichotillomania predicts more positive treatment outcomes, irrespective of treatment type.

Microglia are the resident macrophages of the central nervous system. They play key roles in brain development, and physiology during life and aging. Equippe...

Recent research suggests the brain might host its own microbiome, challenging the long-held belief that it is a sterile organ.

The brain was once thought to be sterile, thanks to the blood-brain barrier. But scientists are beginning to question this.

A new study reveals the brain complexity that underpins expectation and perception when it comes to liking or disliking hot sauce.

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