Nootropics & Psychedelics

Read our Microdosing Mushrroms Guide to find out how microdosing psilocybin can help with depression, anxiety or mood disorders.

The first long-term comparison of psilocybin vs an SSRI for MDD suggests the psychedelic was associated with better overall efficacy and fewer side effects.

A meta-analysis indicates that high-dose psilocybin slightly outperforms escitalopram for treating depression. However, the research also suggests previous estimates of psychedelics' efficacy have been overstated due to issues with blinding in trials.

The FDA did not approve the first psychedelic therapy it considered—which could make the field re-think its approach.

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The prospect of discovering compounds that improve the brain is tantalising, but does the hype match the research?

His findings showed that psilocybin "desynchronized" the brain, but also produced subtle, lasting effects in boosting plasticity.

Comedian and actor Hannah Gadsby quipped in her hit show Nanette that she identified as [pause for dramatic effect] “tired”. In a monologue that resonated with many hard truths, that one particularly struck home for me. The common refrain is so many of us are exhausted, have trouble sleeping, can’t concentrate, and can’t seem to get even simple tasks done without a baffling amount of procrastination. It’s hardly surprising therefore that a large...

Scouted selects products independently. If you purchase something from our posts, we may earn a small commission. If you constantly deal with low energy, brain fog, and inability to focus, it's always a good idea to consult your physician to rule out any underlying health problems, but if you’re looking for a little pick-me-up for the occasional slump, a nootropic supplement may help. There are hundreds of supplements on the market touted for...

A small new study shows reactions in the brain in people who were given psilocybin in a controlled setting.

Nature - Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to...

The active chemical in magic mushrooms could prove to be a powerful antidepressant, a new review finds. Psilocybin outperformed a variety of control treatments

As long as you don't mind needles.

Northwestern University researchers have uncovered how ketamine delivers rapid and prolonged depression relief by activating new neurons for immediate effects and increasing their production for lasting benefits. This breakthrough could lead to safer, ketamine-inspired antidepressants.

Researchers found that ketamine reduces "giving up" behavior in zebrafish by altering astrocyte activity, suggesting its antidepressant effects involve non-neuronal brain cells and promoting resilience against futility-induced passivity.