C Difficile

Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult …

The BHAT improved clinicians' comfort level discussing patient's bowel habits. Health care providers found the BHAT useful and related to their work. This tool shows promise in improving providers' comfort discussing bowel habits and diagnosing Clostridioides difficile in a timely manner.

Recursion and Exscientia, two pioneers in artificial intelligence (AI)-based drug development, have completed a business combination that they vowed will enhance their ability to carry out drug discovery that is both first-in-class and best-in-class.

By outlining a structured approach for the development and evaluation of CDS interventions, with focus on end user engagement, efficiency and feasibility, ASP and IP professionals can leverage CDS to enhance IP/ASP quality improvement initiatives aimed to improve antibiotic utilization, diagnostic s …

CDI in Germany is associated with a high clinical and economic burden, including significantly higher mortality, costs, and healthcare resource utilization, in patients with CDI versus their matched patients without CDI. This has important implications for patients, healthcare providers, and the hea …

For many common infectious diseases in both adult and pediatric populations, a significant body of evidence now shows that short-course antimicrobials are just as ...

Ulcerative colitis (UC) is closely associated with disruptions in gut microbiota. Restoring balance to gut microbiota and reducing intestinal inflammation has become a promising therapeutic approach for UC. However, challenges remain, including limited efficacy in some treatments. This study explore …

Obesity is a serious public health challenge worldwide, the present study is aimed to investigate the structural characteristic and anti-obesity effect of a water-soluble galactomannan (PEC) extracted from Eurotium cristatum (E. cristatum). Detailed analysis of the PEC structure showed a weight-aver …

Clostridioides difficile infections burden US healthcare. Electronic Hand Hygiene Monitoring (EHHMS) systems remind for soap and water. This study evaluates EHHMS effectiveness by comparing C difficile cases in 10 hospitals with CMS data, linking EHHMS use to reduced cases.

Gut microbiota-derived IAA confers a protection against SAE by activating AhR in microglia, improving neuronal and cognitive impairments. Thus, IAA holds the promise as a potential therapeutic agent for managing SAE.

Gut microbiota is generally considered to play an important role in host health due to its extensive immunomodulatory activities. Th17 and Treg cells are two important CD4+ T cell subsets involved in immune regulation, and their imbalance is closely tied to many immune diseases. Recently, abundant r …

For Clostridioides difficile infection (CDI), faecal microbiota transplantation (FMT) is currently recommended for patients with three or more CDI episodes. A recent randomised controlled trial (RCT) show that FMT may be considered early, defined as intervention during the first or second CDI episod …

The different intestinal microbiota communities of HC, IBD, CRA, and CRC patients may be attributed to the different modulation effects of FMT on CRC mice. CRC-FMT promoted, while HC-FMT inhibited the progress of CRC. Increased linoleoyl ethanolamide levels and abundance of Muribaculaceae, Akkermans …

This comprehensive review explores the intricate relationship between gut microbiota, diet, and insulin resistance, emphasizing the novel roles of diet-induced microbial changes in influencing metabolic health. It highlights how diet significantly influences gut microbiota composition, with differen …

Clostridioides difficile infection (CDI) recurs in one of five patients. Monoclonal antibodies targeting the virulence factor TcdB reduce disease recurrence, suggesting that an inadequate anti-TcdB response to CDI leads to recurrence. In patients with CDI, we discovered that IL-33 measured at diagnosis predicts future recurrence, leading us to test the role of IL-33 signaling in the induction of humoral immunity during CDI. Using a mouse recurrence model, IL-33 was demonstrated to be integral for anti-TcdB antibody production. IL-33 acted via ST2+ ILC2 cells, facilitating germinal center T follicular helper (GC-Tfh) cell generation of antibodies. IL-33 protection from reinfection was antibody-dependent, as μMT KO mice and mice treated with anti-CD20 mAb were not protected. These findings demonstrate the critical role of IL-33 in generating humoral immunity to prevent recurrent CDI. ### Competing Interest Statement W.P. is a consultant for TechLab, Inc., which manufactures diagnostic tests for CDI. The authors declare no other competing interests.

Transplantation of gut microbiota from healthy rats significantly enhanced cognitive function in male rats with traumatic brain injury caused by a gas explosion, through the modulation of gut microbiome composition and the improvement of both gut and brain barrier integrity via the gut-brain axis. T …

Acurx is proud to sponsor this inaugural Scientific Symposium of the Peggy Lillis Foundation (PLF) for C. Diff Education & Advocacy An update of ibezapolstat...

"Discover the latest studies in gastroenterology, from capsule endoscopy to novel treatments for IBD, and their implications for the industry in this informativ

The gut microbiome, an ecosystem of trillions of microorganisms in the human digestive tract, has been increasingly linked to chronic diseases

HCMCT Manipal Hospital, Dwarka, marked a decade of transformative healthcare by celebrating 10 years of Fecal Microbiota Transplantation (FMT) therapy in India.In a press statement on Friday, the healthcare provider said, "Introduced in the country on 14th November 2014, this innovative therapy has revolutionised treatment for conditions like chronic gastrointestinal and liver disorders, Parkinson’s Disease, and Autism Spectrum Disorder."The milestone event brought together FMT pioneers, including Dr. (Col) Avnish Seth, recipients, and donors to share experiences and reflect on the life-changing impact of this therapy. Dr. Seth, a leading expert in the field, performed India’s first FMT procedure and has since played a key role in establishing it as a safe and effective treatment at HCMCT Manipal Hospital.“Stool Transplant or FMT represents a paradigm shift in the treatment of certain gut and liver conditions,” said Dr. Seth, Chairman of the Manipal Institute of Gastroenterology & Hepato-Biliary-Pancreatic Sciences. “Except for Clostridium difficile colitis, FMT for other disorders should be conducted only under approved research protocols. It is deeply rewarding to witness patients regain their health through this therapy.”The event highlighted the importance of addressing microbial imbalances at the root cause of diseases rather than merely managing symptoms. Patients and donors shared compelling stories of recovery, emphasising FMT's effectiveness and potential.Hospital Director Viji Varghese underscored the need for greater awareness and accessibility. “Our celebration is not just about the past decade—it’s a commitment to advancing this innovative treatment. We aim to ensure it reaches more individuals who can benefit from its transformative potential,” he stated. 

Difficile associated diarrhea DAD primarily caused by Clostridioides difficile C difficile infection presents a significant healthcare challenge globally This infection is commonly associated with prolonged antibiotic use that disrupts the natural balance of gut flora leading to severe gastrointestinal symptoms ...

The gut microbiota influences multiple aspects of human health and disease. Several studies have indicated an association between the gut microbiota and response to immune checkpoint inhibitors in various cancers, but there is scarce data from breast cancer. The randomized ALICE trial demonstrated i …

Clostridial infections, known for their severity and rapid progression, present significant challenges in both clinical and veterinary fields. These bacteria, which can survive without oxygen and produce protective spores, cause many diseases, ranging from simple gastrointestinal disorders to severe …

People who contracted COVID-19 during the early stages of the pandemic had an increased risk of myocardial infarction (heart attack), stroke, and death for the next 3 years, according to a study sponsored by the National Institutes of Health (NIH).

With the rising prevalence of chronic liver diseases worldwide, there exists a need to diversify our artillery to incorporate a plethora of diagnostic and therapeutic methods to combat this disease. Currently, the most common causes of liver disease are non-alcoholic fatty liver disease, hepatitis, …

Colorectal cancer (CRC) constitutes a significant global health challenge, with recent studies underscoring the pivotal role of the gut microbiome in its pathogenesis and progression. Fecal microbiota transplantation (FMT) has emerged as a compelling therapeutic approach, offering the potential to m …

Amelanotic melanoma (AM) is a subtype of hypomelanotic or completely amelanotic melanoma. AM is a rare subtype of melanoma that exhibits a higher recurrence rate and aggressiveness as well as worse surveillance than typical melanoma. AM shows a dysregulation of melanin production, cell cycle control …

Microbiota-gut-brain axis, the bidirectional relationship between the gut microbiota and the brain, has been increasingly appreciated in the pathogenesis of Parkinson's disease (PD). Fucoidan, a sulphate-rich polysaccharide, has been shown to be neuroprotective by reducing oxidative stress in PD mod …